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Titolo:
THE USE OF ANTIBODIES AGAINST THE IL-2 RECEPTOR IN TRANSPLANTATION
Autore:
WALDMANN TA; OSHEA J;
Indirizzi:
NCI,NIH,10 CTR DR,MSC 1374,10-4N115 BETHESDA MD 20892 NIAMSD,NIH BETHESDA MD 20892
Titolo Testata:
Current opinion in immunology
fascicolo: 5, volume: 10, anno: 1998,
pagine: 507 - 512
SICI:
0952-7915(1998)10:5<507:TUOAAT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC ALLOGRAFT SURVIVAL; T-CELL LEUKEMIA; YTTRIUM-90-LABELED ANTI-TAC; JAK-3 JANUS KINASE; MICE LACKING JAK3; INTERLEUKIN-2 RECEPTOR; MONOCLONAL-ANTIBODY; HUMANIZED ANTIBODY; BETA-CHAIN; GAMMA-CHAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Waldmann e J. Oshea, "THE USE OF ANTIBODIES AGAINST THE IL-2 RECEPTOR IN TRANSPLANTATION", Current opinion in immunology, 10(5), 1998, pp. 507-512

Abstract

Humanized monoclonal antibodies that recognize the a chain of the IL-2 receptor (e.g. daclizumab) have been used to prevent allograft rejection, since this chain is expressed by T cells participating in allograft rejection but not by resting T cells. In a randomized trial, when added to standard cyclosporin-based immunosuppression, daclizumab significantly reduced the frequency of acute rejection of renal transplants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:20:15