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Titolo:
ENHANCED ENERGY-METABOLISM AT HYPOTHERMIA FOLLOWING ADDITION OF A PROSTACYCLIN DERIVATIVE IN PORCINE LIVER
Autore:
CHANGANI KK; DAVIDSON BR; BELL JD; TAYLORROBINSON SD; FULLER BJ;
Indirizzi:
ROYAL FREE HOSP,DEPT SURG,ROWLAND HILL ST LONDON NW3 2QG ENGLAND UNIV LONDON SCH MED LONDON NW3 2QG ENGLAND HAMMERSMITH HOSP,SCH MED,IMPERIAL COLL,ROBERT STEINER NMR UNIT LONDONW12 0NN ENGLAND HAMMERSMITH HOSP,SCH MED,IMPERIAL COLL,DEPT GASTROENTEROL LONDON W12 0NN ENGLAND
Titolo Testata:
Cryo-letters
fascicolo: 3, volume: 19, anno: 1998,
pagine: 131 - 140
SICI:
0143-2044(1998)19:3<131:EEAHFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGENERATION; PRESERVATION; ISCHEMIA;
Keywords:
PROSTACYCLIN; ATP REGENERATION; P-31-NMR; COLD ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Changani et al., "ENHANCED ENERGY-METABOLISM AT HYPOTHERMIA FOLLOWING ADDITION OF A PROSTACYCLIN DERIVATIVE IN PORCINE LIVER", Cryo-letters, 19(3), 1998, pp. 131-140

Abstract

This study set out to evaluate the effect of a prostacyclin derivative on the dynamics of energy metabolism in the hypothermic liver, both in the presence or absence of oxygen. Pig livers were harvested according to clinical protocol and cold stored in University of Wisconsin UW) solution with or without a prostacyclin derivative (iloprost - 10(-8)mmol/l). Livers were positioned in a 1.5 Tesla NMR scanner and phosphorus-31 spectra collected every 2 minutes during the period of cold hypoxia and were subjected to oxygenated hypothermic reperfusion (HtR). From the beta-NTP (nucleotide triphosphates which contains ATP) regeneration profiles following HtR, the iloprost group produced +59.6% (p<0.01) more beta-NTP compared to the control UW group. The initial rate of beta-NTP regeneration in the iloprost group was +66.3% greater (p<0.001). Conversely, during hypoxia, when HtR was stopped, the depletionrate of NTP was 32.6% slower (p<0.02) compared with the control UW group. The results show that the inclusion of the prostacyclin derivative, iloprost, to existing organ preservation solutions may have a beneficial effect on organ viability, with respect to bioenergetic integrity, following short term cold hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 04:57:06