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Titolo:
LYMPHOKINE-ACTIVATED KILLER (LAK) CELL ANTI-HIV-1 ADCC REACTIVITY - APOTENTIAL STRATEGY FOR REDUCTION OF VIRUS-INFECTED CELLULAR RESERVOIRS
Autore:
TYLER DS; STANLEY SD; BARTLETT JA; BOLOGNESI DP; WEINHOLD KJ;
Indirizzi:
DUKE UNIV,MED CTR,DEPT SURG DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT MED DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT IMMUNOL DURHAM NC 27710
Titolo Testata:
The Journal of surgical research (Print)
fascicolo: 2, volume: 79, anno: 1998,
pagine: 115 - 120
SICI:
0022-4804(1998)79:2<115:LK(CAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY SYNDROME; NATURAL-KILLER; CYTO-TOXICITY; EFFECTOR-CELLS; HIV-1 INFECTION; SYNDROME AIDS; RECOMBINANT INTERLEUKIN-2; ANTIRETROVIRAL THERAPY; GLYCOPROTEIN GP120;
Keywords:
ADCC; LAK CELLS; NK/K CELLS; INTERLEUKIN-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Tyler et al., "LYMPHOKINE-ACTIVATED KILLER (LAK) CELL ANTI-HIV-1 ADCC REACTIVITY - APOTENTIAL STRATEGY FOR REDUCTION OF VIRUS-INFECTED CELLULAR RESERVOIRS", The Journal of surgical research (Print), 79(2), 1998, pp. 115-120

Abstract

Lymphocytes from HIV-l-seropositive and -sero-negative individuals were examined to determine whether HIV-1 infection interfered with the ability to generate a lymphokine-activated killer (LAK) cell response. Following a 3-day ex vivo incubation in the presence of 1000 U/ml of recombinant interleukin-a, lymphocytes from seropositive individuals exhibited a LAK cell response which was equivalent to or greater than that of seronegative controls as measured against Daudi cell targets. LAM cells from seropositive and seronegative donors showed no specific cytolytic activity against gp120-coated or HIV-1-infected targets. However, in the presence of patient sera, significant levels of virus-specific LAK cell-mediated antibody-dependent cellular cytotoxicity (ADCC)were observed. The level of this specific LAK cell-mediated ADCC was greater than that mediated under similar conditions by freshly isolated peripheral blood mononuclear cells. The greatest improvement in ADCCover baseline activity was seen with lymphocytes from AIDS patients after the 3-day ex vivo activation, suggesting that this patient population might benefit the most from adaptive LAK cell therapy. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:19:23