Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEPRESSION OF LIVER MITOCHONDRIAL COMPLEX II-LINKED RESPIRATION FOLLOWING COOLING - BENEFICIAL-EFFECTS OF USING A PROSTACYCLIN ANALOG DURING HYPOTHERMIA
Autore:
CHANGANI KK; BELL JD; BROOKS KJ; FULLER BJ; TAYLORROBINSON SD; DAVIDSON BR; BROOKES PS; BATES TE;
Indirizzi:
ROYAL FREE HOSP & MED SCH,DEPT SURG,ROWLAND HILL ST LONDON NW3 2QG ENGLAND HAMMERSMITH HOSP,ROBERT STEINER NMR UNIT LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,DEPT GASTROENTEROL LONDON W12 0NN ENGLAND INST NEUROL,DEPT NEUROCHEM LONDON WC1N 3BG ENGLAND
Titolo Testata:
Cryo-letters
fascicolo: 2, volume: 19, anno: 1998,
pagine: 71 - 78
SICI:
0143-2044(1998)19:2<71:DOLMCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGAN PRESERVATION; PROSTAGLANDIN E(1); FREE-RADICALS; TRANSPLANTATION; INJURY; EUROCOLLINS; ILOPROST; ISCHEMIA; 24-HOUR; DAMAGE;
Keywords:
PROSTACYCLIN; MITOCHONDRIAL RESPIRATORY CHAIN; COLD ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Changani et al., "DEPRESSION OF LIVER MITOCHONDRIAL COMPLEX II-LINKED RESPIRATION FOLLOWING COOLING - BENEFICIAL-EFFECTS OF USING A PROSTACYCLIN ANALOG DURING HYPOTHERMIA", Cryo-letters, 19(2), 1998, pp. 71-78

Abstract

The role of mitochondria in the storage and preservation of organs has not fully been investigated. We investigated the hypothesis that theaddition of a prostacyclin analogue to preservation solution improvedATP regeneration profiles of stored liver by protecting mitochondrialfunction. Oxidative phosphorylation was investigated in isolated rat liver mitochondria following a period of cold ischaemic preservation with University of Wisconsin solution plus/minus the prostacyclin analogue, iloprost (10(-8)mol/l). In state 4 respiration (+ substrates -ADP) iloprost doubled oxygen consumption rates for both complex I and II. In state 3 (+ substrates + ADP), iloprost doubled the complex II linked respiration rate, with no significant effect on complex I. Enzyme activity of complex II, measured spectrophotometrically, showed no increase in the presence of iloprost. These results imply that iloprost protects complex II function within the inner mitochondrial membrane during cold ischaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:06:54