Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IDENTIFICATION OF A 28 KDA SECRETORY PROTEIN FROM RAT OLFACTORY EPITHELIUM AS A THIOL-SPECIFIC ANTIOXIDANT
Autore:
PESHENKO IV; NOVOSELOV VI; EVDOKIMOV VA; NIKOLAEV YV; KAMZALOV SS; SHUVAEVA TM; LIPKIN VM; FESENKO EE;
Indirizzi:
RUSSIAN ACAD SCI,INST CELL BIOL PUSHCHINO 142292 MOSCOW REGION RUSSIA RUSSIAN ACAD SCI,SHEMYAKIN & OVCHINNIKOV INST BIOORGAN CHEM MOSCOW RUSSIA
Titolo Testata:
Free radical biology & medicine
fascicolo: 6, volume: 25, anno: 1998,
pagine: 654 - 659
SICI:
0891-5849(1998)25:6<654:IOA2KS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKYL HYDROPEROXIDE REDUCTASE; NONSELENIUM GLUTATHIONE-PEROXIDASE; SALMONELLA-TYPHIMURIUM; GLUTAMINE-SYNTHETASE; CATALYZED OXIDATION; S-TRANSFERASES; PURIFICATION; CELL; CONSEQUENCES; MECHANISM;
Keywords:
THIOL-SPECIFIC ANTIOXIDANT; PEROXIREDOXIN; SECRETORY PROTEIN; OLFACTORY EPITHELIUM; RAT; FREE RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
I.V. Peshenko et al., "IDENTIFICATION OF A 28 KDA SECRETORY PROTEIN FROM RAT OLFACTORY EPITHELIUM AS A THIOL-SPECIFIC ANTIOXIDANT", Free radical biology & medicine, 25(6), 1998, pp. 654-659

Abstract

The 28 kDa secretory protein is one of the abundant water-soluble proteins in olfactory epithelium of mammals. Analysis of partial amino acid sequence of the 28 kDa protein strongly suggested that it belongs to a new family of highly conserved antioxidant proteins requiring thiol for their antioxidant activity (TSA/AhpC family). In the present study, we found the 28 kDa protein to have thiol-dependent antioxidant activity, thereby protecting radical-sensitive proteins such as glutamine synthetase and hemoglobin from oxidative modification caused by thiol-dependent metal ion-catalyzed oxidation system. The purified 28 kDa protein did not possess catalase or glutathione peroxidase activities,and required thiols to exhibit its antioxidant activity. The 28 kDa protein is the first member of the family of thiol-specific antioxidants identified in olfactory epithelium and the first secretory protein shown to be thiol-specific antioxidant. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 23:35:29