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Titolo:
MOOD CORRELATES WITH BLOOD SEROTONIN, BUT NOT WITH GLUCOSE MEASURES IN PATIENTS WITH RECURRENT SUICIDAL-BEHAVIOR
Autore:
VERKES RJ; HENGEVELD MW; VANDERMAST RC; FEKKES D; VANKEMPEN GMJ;
Indirizzi:
UNIV NIJMEGEN HOSP,DEPT PSYCHIAT,POB 9101 NL-6500 HB NIJMEGEN NETHERLANDS LEIDEN UNIV,MED CTR,DEPT PSYCHIAT NL-2300 RC LEIDEN NETHERLANDS PSYCHIAT HOSP AMSTERDAM NL-1054 AG AMSTERDAM NETHERLANDS ERASMUS UNIV,SECT PATHOPHYSIOL BEHAV NL-3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Psychiatry research
fascicolo: 3, volume: 80, anno: 1998,
pagine: 239 - 248
SICI:
0165-1781(1998)80:3<239:MCWBSB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; PLATELET SEROTONIN; WHOLE-BLOOD; DEPRESSED-PATIENTS; TOLERANCE TEST; TRYPTOPHAN DEPLETION; D-FENFLURAMINE; PLASMA NEUROTRANSMITTERS; IMIPRAMINE BINDING; HABITUALLY VIOLENT;
Keywords:
SUICIDE ATTEMPTS; DEPRESSION; AGGRESSION; SEROTONIN; GLUCOSE; PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Verkes et al., "MOOD CORRELATES WITH BLOOD SEROTONIN, BUT NOT WITH GLUCOSE MEASURES IN PATIENTS WITH RECURRENT SUICIDAL-BEHAVIOR", Psychiatry research, 80(3), 1998, pp. 239-248

Abstract

Depressive mood and impulsive-aggressive behavior are relevant to suicidal behavior and have been associated with decreased central serotonergic function. Impulsive behavior and aggression have also been related to abnormal glucose metabolism. To investigate these relationships further, blood serotonin (5-HT), blood glucose measures (glycated hemoglobin (HbA(1C)) and fructosamine) and self-reported depressive symptoms and anger were repeatedly measured, during a 1-year follow-up, in 106 patients who had recently attempted suicide for at least a second time. A major DSM-III-R Axis I diagnosis or use of antidepressants werereasons for exclusion. Intra-individual variations in blood 5-HT wereinversely correlated with variations in depressive mood, self-depreciation, and anger, and positively with variations in fructosamine. Intra-individual variations of HbA(1C) or fructosamine were not correlatedwith mood. Mean blood 5-HT levels per patient were positively correlated with mean scores of depression and self-depreciation. The contrastbetween the intra-individual and the inter-individual correlations may reflect a difference between short- vs. long-term effects. The results do support an association between serotonergic function and mood, but not between glucose metabolism and mood, in recurrent suicide attempters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 25/01/20 alle ore 01:18:32