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Titolo:
TISSUE NERVE GROWTH-FACTOR CONCENTRATIONS IN NEUROMUSCULAR DISEASES
Autore:
STUERENBURG HJ; KUNZE K;
Indirizzi:
UNIV HOSP HAMBURG EPPENDORF,DEPT NEUROL HAMBURG GERMANY
Titolo Testata:
European journal of neurology
fascicolo: 5, volume: 5, anno: 1998,
pagine: 487 - 490
SICI:
1351-5101(1998)5:5<487:TNGCIN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
2-SITE ENZYME-IMMUNOASSAY; DIABETIC NEUROPATHY; FACTOR NGF; EXPRESSION; BRAIN;
Keywords:
NERVE GROWTH FACTOR; AMYOTROPHIC LATERAL SCLEROSIS; NEUROMUSCULAR DISEASES; MUSCLE BIOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Stuerenburg e K. Kunze, "TISSUE NERVE GROWTH-FACTOR CONCENTRATIONS IN NEUROMUSCULAR DISEASES", European journal of neurology, 5(5), 1998, pp. 487-490

Abstract

In order to investigate the possible influences of pathological processes on muscle NGF levels in human subjects, we measured the NGF concentrations in muscle biopsies from 35 male and 16 female subjects (controls, n = 14; amyotrophic lateral sclerosis, n = 20; inflammatory myopathy, n = 6; muscular dystrophy, n = 11). The NGF concentration in each group was as follows: controls, 1.73 +/- 0.3 pg/mg protein (mean +/-S.E.M.); muscular dystrophies, 1.73 +/- 0.48 pg/mg protein; inflammatory myopathies, 2.28 +/- 1.45 pg/mg protein; amyotrophic lateral sclerosis, 4.15 +/- 0.79 pg/mg protein. The tissue NGF concentrations were significantly (140%) higher in patients with ALS than in the control subjects (P < 0.05, Wilcoxon signed rank test). Age and gender had no influence on tissue NGF concentrations. We conclude that the NGF increases observed here in affected muscle in amyotrophic lateral sclerosis can best be explained in terms of rapidly progressing denervation processes. (C) 1998 Lippincott Williams & Wilkins.

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Documento generato il 30/10/20 alle ore 00:15:03