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Titolo:
CHEMOKINE CORECEPTOR USAGE BY DIVERSE PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
Autore:
ZHANG LQ; HE T; HUANG YX; CHEN ZW; GUO Y; WU S; KUNSTMAN KJ; BROWN RC; PHAIR JP; NEUMANN AU; HO DD; WOLINSKY SM;
Indirizzi:
ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,455 1ST AVE,7TH FLOOR NEWYORK NY 10016 NORTHWESTERN UNIV,SCH MED,DEPT MED CHICAGO IL 60611 BAR ILAN UNIV,DEPT LIFE SCI IL-52900 RAMAT GAN ISRAEL
Titolo Testata:
Journal of virology (Print)
fascicolo: 11, volume: 72, anno: 1998,
pagine: 9307 - 9312
SICI:
0022-538X(1998)72:11<9307:CCUBDP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE SUBTYPE-A; DISEASE PROGRESSION; HIV-1 INFECTION; BIOLOGICAL PHENOTYPE; GENETIC-VARIATION; FUSION COFACTOR; VIRAL PHENOTYPE; TROPIC HIV-1; RECEPTOR; CCR5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
L.Q. Zhang et al., "CHEMOKINE CORECEPTOR USAGE BY DIVERSE PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1", Journal of virology (Print), 72(11), 1998, pp. 9307-9312

Abstract

We tested chemokine receptor subset usage by diverse, well-characterized primary viruses isolated from peripheral blood by monitoring viralreplication with CCR1, CCR2b, CCR3, CCR5, and CXCR4 U87MG.CD4 transformed cell lines and STRL33/BONZO/TYMSTR and GPR15/BOB HOS.CD4 transformed cell lines. primary viruses were isolated from 79 men with confirmed human immunodeficiency virus type 1 (HIV-1) infection from the Chicago component of the Multicenter AIDS Cohort Study at interval time points. Thirty-five additional well-characterized primary viruses representing HIV-1 group M subtypes A, B, C, D, and E and group O and three primary simian immunodeficiency virus (SIV) isolates were also used for these studies. The restricted use of the CCR5 chemokine receptor forviral entry was associated with infection by a virus having a non-syncytium-inducing phenotype and correlated with a reduced rate of disease progression and a prolonged disease-free interval. Conversely, broadening chemokine receptor usage from CCR5 to both CCR5 and CXCR4 was associated with infection by a virus having a syncytium-inducing phenotype and correlated with a faster rate of CD4 T-cell decline and progression of disease. We also observed a greater tendency for infection with a virus having a syncytium-inducing phenotype in men heterozygous for the defective CCR5 Delta 32 allele (25%) than in those men homozygous for the wild-type CCR5 allele (6%) (P = 0.03), The propensity for infection with a virus having a syncytium-inducing phenotype provides a partial explanation for the rapid disease progression among some men heterozygous for the defective CCR5 Delta 32 allele, Furthermore, we did not identify any primary viruses that used CCR3 as an entry cofactor, despite this CC chemokine receptor being expressed on the cell surface at a level commensurate with or higher than that observed for primary peripheral blood mononuclear cells. Whereas isolates of primary viruses of SIV also used STRL33/BONZO/TYMSTR and GPR15/BOB, no primary isolates of HN-P used these particular chemokine receptor-like orphan molecules as entry cofactors, suggesting a limited contribution of theseother chemokine receptors to viral evolution, Thus, despite the number of chemokine receptors implicated in viral entry, CCR5 and CXCR4 arelikely to be the physiologically relevant chemokine receptors used asentry cofactors in vivo by diverse strains of primary viruses isolated from blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:37:41