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Titolo:
RHESUS MACAQUES INFECTED WITH MACROPHAGE-TROPIC SIMIAN IMMUNODEFICIENCY VIRUS (SIV(MAC)R71 17E) EXHIBIT EXTENSIVE FOCAL SEGMENTAL AND GLOBAL GLOMERULOSCLEROSIS/
Autore:
STEPHENS EB; TIAN CQ; LI Z; NARAYAN O; GATTONE VH;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT MICROBIOL MOL GENET & IMMUNOL KANSAS CITY KS66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160
Titolo Testata:
Journal of virology (Print)
fascicolo: 11, volume: 72, anno: 1998,
pagine: 8820 - 8832
SICI:
0022-538X(1998)72:11<8820:RMIWMS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-ASSOCIATED NEPHROPATHY; ENZYMATIC AMPLIFICATION; TRANSGENIC MODELS; SIVMAC INFECTION; NERVOUS-SYSTEM; TYPE-1; AIDS; PATHOGENESIS; DETERMINANTS; MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Stephens et al., "RHESUS MACAQUES INFECTED WITH MACROPHAGE-TROPIC SIMIAN IMMUNODEFICIENCY VIRUS (SIV(MAC)R71 17E) EXHIBIT EXTENSIVE FOCAL SEGMENTAL AND GLOBAL GLOMERULOSCLEROSIS/", Journal of virology (Print), 72(11), 1998, pp. 8820-8832

Abstract

We previously showed that inoculation of rhesus macaques with molecularly cloned lymphocytetropic simian immunodeficiency virus (SIV(mac)239) results in SIV-associated nephropathy (SIVAN) and that the glomerulo-sclerotic lesions were associated with the selection of macrophagetropic (M-tropic) variants (V. H. Gattone et al., AIDS Res. Hum, Retroviruses 14:1163-1180, 1998), In the present study, seven rhesus macaqueswere inoculated with M-tropic SIV(mac)R71/17E, and the renal pathology was examined at necropsy. All SIV(mac)R71/17E-infected macaques developed AIDS, and most developed other systemic complications, includingSIV-induced encephalitis and lentivirus interstitial pneumonia, Therewas no correlation between the length of infection (42 to 97 days), circulating CD4(+) T-cell counts, and renal disease. Of the seven macaques inoculated with SIV(mac)R71/17E, five developed significant mesangial hyperplasia and expansion of matrix and four were clearly azotemic(serum urea nitrogen concentration of 40 to 112 mg/dl), These same five macaques developed focal segmental to global glomerulosclerotic lesions, Increased numbers of glomerular CD68(+) cells (monocytes/macrophages) were found in glomeruli but not the tubulointerstitium of the macaques inoculated with SIV(mac)R71/17E. All macaques had glomerular deposits of immunoglobulin G (IgG), IgM, and tubuloreticular inclusions,and sis of seven had IgA deposition, However, there was no correlation between the presence of circulating anti-SIVmac antibodies, immunoglobulin deposition, and glomerular disease. Tubulointerstitial infiltrates were mild, with little or no correlation to azotemia, while microcystic tubules were evident in those with glomerulosclerosis or azotemia, The four most severely affected macaques were positive for diffuse glomerular immunostaining for viral core p27 antigen, and there was intense staining in the glomeruli of the two macaques with the most severe glomerulosclerosis. Viral sequences were isolated from glomerular and tubulointerstitial fractions from macaques with severe glomerulosclerosis but only from the tubulointerstitial compartment of those that did not develop glomerulosclerosis, Interviral recombinant viruses generated with env sequences isolated from glomeruli confirmed the M-tropic nature of the virus found in the glomeruli. The correlation betweenthe increased number, of CD68(+) cells (monocytes/macrophages) in theglomeruli, the localization of p27 antigen in the glomeruli, and the glomerular pathology confirms and extends our previous observations ofan association between glomerular infection and infiltration by M-tropic virus and SIVAN.

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Documento generato il 30/11/20 alle ore 03:23:40