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Titolo:
POTENTIAL CONTRIBUTIONS OF VIRAL ENVELOPE AND HOST GENETIC-FACTORS INA HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED LONG-TERM SURVIVOR
Autore:
GROVITFERBAS K; FERBAS J; GUDEMAN V; SADEGHI S; GOETZ MB; GIORGI JV; CHEN ISY; OBRIEN WA;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,DIV HEMATOL ONCOL,11-934 FACTOR LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,DIV HEMATOL ONCOL LOS ANGELESCA 90095 UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,AIDS INST LOS ANGELES CA 90095 VET ADM MED CTR LOS ANGELES CA 90073
Titolo Testata:
Journal of virology (Print)
fascicolo: 11, volume: 72, anno: 1998,
pagine: 8650 - 8658
SICI:
0022-538X(1998)72:11<8650:PCOVEA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-INFECTED ADULTS; CD8(+) T-CELLS; DISEASE PROGRESSION; CUBIC MILLIMETER; CHEMOKINE RECEPTORS; ANTIBODY-RESPONSES; FUSION COFACTOR; ACCESSORY GENES; NEF SEQUENCES; TROPIC HIV-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
K. Grovitferbas et al., "POTENTIAL CONTRIBUTIONS OF VIRAL ENVELOPE AND HOST GENETIC-FACTORS INA HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED LONG-TERM SURVIVOR", Journal of virology (Print), 72(11), 1998, pp. 8650-8658

Abstract

The Lack of clinical progression in some individuals despite prolonged human immunodeficiency virus type 1 (HIV-1) infection may result from infection with less-pathogenic viral strains. To address this question, we examined the IIIV-1 en;elope protein from a donor with a low viral burden, stable CD4(+) T-lymphocyte counts, and little evidence of CD8(+) T-cell expansion, activation, or immune activity. To avoid potential changes in envelope function resulting from selection in vitro, envelope clones were constructed by using viral RNA isolated from uncultured peripheral blood mononuclear cells (PBMC). The data showed thatrecombinant viruses containing envelope sequences derived from RNA isolated from patient PBMC replicated poorly in primary CD4(+) T cells but demonstrated efficient growth in macrophages. The unusual phenotypeof these viruses could not be explained solely by differential utilization of coreceptors since the chimeric viruses, as well as an uncloned isolate obtained from the same visit date, can utilize CCR5. In addition, the donor's own cells appeared resistant to infection with chimeric viruses containing autologous envelope sequences. Genotype analysis revealed that the donor was heterozygous for the previously described 32-bp deletion in CCR5 which may be linked with prolonged survival in IIIV-1-infected individuals. These data suggest that the changes in envelope sequences confer properties of viral attenuation, which together with the CCR5 +/Delta 32 genotype could account for the long-term survival of this patient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:05:17