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Titolo:
PERFUSION OF COLORECTAL LIVER METASTASES AND UPTAKE OF FLUOROURACIL ASSESSED BY (H2O)-O-15 AND [F-18] URACIL POSITRON EMISSION TOMOGRAPHY (PET)
Autore:
HOHENBERGER P; STRAUSS LG; LEHNER B; FROHMULLER S; DIMITRAKOPOULOU A; SCHLAG P;
Indirizzi:
FREE UNIV BERLIN,HOSP RUDOLF VIRCHOW,ROBERT ROSSLE KLIN ONKOL,MAX DELBRUCK ZENTRUM MOLEK MED O-1115 BERLIN GERMANY UNIV HEIDELBERG,DEPT SURG,SURG ONCOL SECT W-6900 HEIDELBERG GERMANY GERMAN CANC RES CTR,DEPT DIAGNOST RADIOL & PATHOPHYSIOL W-6900 HEIDELBERG 1 GERMANY
Titolo Testata:
European journal of cancer
fascicolo: 12, volume: 29A, anno: 1993,
pagine: 1682 - 1686
SICI:
0959-8049(1993)29A:12<1682:POCLMA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ARTERIAL INFUSION; SYSTEMIC CHEMOTHERAPY; STARCH MICROSPHERES; CLINICAL ONCOLOGY; RANDOMIZED TRIAL; TUMOR UPTAKE; CANCER; 5-FU; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P. Hohenberger et al., "PERFUSION OF COLORECTAL LIVER METASTASES AND UPTAKE OF FLUOROURACIL ASSESSED BY (H2O)-O-15 AND [F-18] URACIL POSITRON EMISSION TOMOGRAPHY (PET)", European journal of cancer, 29A(12), 1993, pp. 1682-1686

Abstract

Perfusion and fluorouracil (FU) accumulation were assessed using positron emission tomography (PET) with (H2O)-O-15 and (FU)-F-18 in 36 patients with colorectal liver metastases. The tracers were injected intravenously and via the hepatic artery. Standard uptake values (SUV) were calculated using a region of interest (ROI) technique. The perfusionof non-tumorous liver tissue was similar after intravenous (i.v.) andintra-arterial (i.a.) assessment [mean of 2.67 (s = 0.61) and 2.2 (s = 0.45)]. Metastases were found to be hypoperfused compared to normal liver tissue after i.v. examinations [mean 1.73 (s = 0.77)]; i.a. injections revealed greater perfusion in metastases [mean 6.41 (s = 5.47)]. Single metastases showed up to 10 times greater perfusion with the i.a. injection route than with the i.v. one. However, lesions with no change or lower perfusion were also observed. Generally, accumulation of (FU)-F-18 in metastases after i.v. infusion was less than after i.a.. Correlation of i.v. perfusion and uptake was moderate (r = 0.54, P =0.0001); i.a. correlation was only slightly better (r = 0.61, P = 0.008). Perfusion as measured by (H2O)-O-15-PET does not generally predict uptake of (FU)-F-18 in colorectal liver metastases. To measure FU uptake using PET and F-18 seems to be the most accurate method. It wouldallow one to identify individual patients with considerably greater accumulation of (FU)-F-18 following i. a. administration who should profit from a cross-over to intrahepatic chemotherapy.

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Documento generato il 25/01/21 alle ore 16:25:30