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Titolo:
IMPAIRED RECRUITMENT OF THE HIPPOCAMPUS DURING CONSCIOUS RECOLLECTIONIN SCHIZOPHRENIA
Autore:
HECKERS S; RAUCH SL; GOFF D; SAVAGE CR; SCHACTER DL; FISCHMAN AJ; ALPERT NM;
Indirizzi:
MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,PSYCHOT DISORDERS UNIT BOSTON MA02114 MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,PSYCHIAT NEUROIMAGING RES GRP BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,POSITRON EMISS TOMOG LAB BOSTON MA 02114 HARVARD UNIV,DEPT PSYCHOL CAMBRIDGE MA 02138
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 1, anno: 1998,
pagine: 318 - 323
SICI:
1097-6256(1998)1:4<318:IROTHD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; EPISODIC MEMORY; FUNCTIONAL NEUROANATOMY; RECOGNITION MEMORY; TEMPORAL-LOBE; DYSFUNCTION; BRAIN; MEDICATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S. Heckers et al., "IMPAIRED RECRUITMENT OF THE HIPPOCAMPUS DURING CONSCIOUS RECOLLECTIONIN SCHIZOPHRENIA", NATURE NEUROSCIENCE, 1(4), 1998, pp. 318-323

Abstract

Poor attention and impaired memory are enduring and core features of schizophrenia. These impairments have been attributed either to globalcortical dysfunction or to perturbations of specific components associated with the dorsolateral prefrontal cortex (DLPFC), hippocampus andcerebellum. Here, we used positron emission tomography (PET) to dissociate activations in DLPFC and hippocampus during verbal episodic memory retrieval. We found reduced hippocampal activation during consciousrecollection of studied words, but robust activation of the DLPFC during the effort to retrieve poorly encoded material in schizophrenic patients. This finding provides the first evidence of hippocampal dysfunction during episodic memory retrieval in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 22:59:04