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Titolo:
DRUG-INTERACTIONS WITH NEWER ANTIDEPRESSANTS - ROLE OF HUMAN CYTOCHROMES P450
Autore:
GREENBLATT DJ; VONMOLTKE LL; HARMATZ JS; SHADER RI;
Indirizzi:
TUFTS UNIV,SCH MED,DEPT PHARMACOL & EXPT THERAPEUT,136 HARRISON AVE BOSTON MA 02111 TUFTS UNIV,SCH MED,DIV CLIN PHARMACOL BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR BOSTON MA 02111
Titolo Testata:
The Journal of clinical psychiatry
, volume: 59, anno: 1998, supplemento:, 15
pagine: 19 - 27
SICI:
0160-6689(1998)59:<19:DWNA-R>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER-MICROSOMES; HYDROXYLATION IN-VITRO; CLINICAL PHARMACOKINETICS; N-DEMETHYLATION; FLUVOXAMINE PHARMACOKINETICS; DESIPRAMINE METABOLISM; DEPRESSIVE-ILLNESS; POOR METABOLIZERS; FLUOXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Greenblatt et al., "DRUG-INTERACTIONS WITH NEWER ANTIDEPRESSANTS - ROLE OF HUMAN CYTOCHROMES P450", The Journal of clinical psychiatry, 59, 1998, pp. 19-27

Abstract

Selective serotonin reuptake inhibitors and related antidepressant compounds have the secondary pharmacologic property of inhibiting the activity of human cytochrome P350 enzymes responsible for the oxidative metabolism of many drugs. A number of clinically important pharmacokinetic drug interactions are a consequence of these cytochrome inhibiting effects. This review evaluates the clinical implications of the metabolic profiles of the newer antidepressants, the relative activities of various new antidepressants as inhibitors of human cytochrome P450, and the various in vivo and in vitro methodologies that can be used for identification and quantification of drug interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:14:06