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Titolo:
BRAIN-SEROTONIN NEUROTRANSMISSION - AN OVERVIEW AND UPDATE WITH AN EMPHASIS ON SEROTONIN SUBSYSTEM HETEROGENEITY, MULTIPLE RECEPTORS, INTERACTIONS WITH OTHER NEUROTRANSMITTER SYSTEMS, AND CONSEQUENT IMPLICATIONS FOR UNDERSTANDING THE ACTIONS OF SEROTONERGIC DRUGS
Autore:
MURPHY DL; ANDREWS AM; WICHEMS CH; LI Q; TOHDA M; GREENBERG B;
Indirizzi:
NIMH,CLIN SCI LAB,INTRAMURAL RES PROGRAM,CLIN CTR,NIH,10-3D41 BETHESDA MD 20892
Titolo Testata:
The Journal of clinical psychiatry
, volume: 59, anno: 1998, supplemento:, 15
pagine: 4 - 12
SICI:
0160-6689(1998)59:<4:BN-AOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ANTIDEPRESSANT TREATMENT; PRIMARY PULMONARY-HYPERTENSION; MEDIAN RAPHE NUCLEI; A-DEFICIENT MICE; REUPTAKE INHIBITORS; 5-HT2C RECEPTOR; ACETYLCHOLINE-RELEASE; AGGRESSIVE-BEHAVIOR; MESSENGER-RNAS; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
118
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Murphy et al., "BRAIN-SEROTONIN NEUROTRANSMISSION - AN OVERVIEW AND UPDATE WITH AN EMPHASIS ON SEROTONIN SUBSYSTEM HETEROGENEITY, MULTIPLE RECEPTORS, INTERACTIONS WITH OTHER NEUROTRANSMITTER SYSTEMS, AND CONSEQUENT IMPLICATIONS FOR UNDERSTANDING THE ACTIONS OF SEROTONERGIC DRUGS", The Journal of clinical psychiatry, 59, 1998, pp. 4-12

Abstract

Knowledge about serotonergic neurotransmission has been expanding rapidly. Recent research has delineated 15 molecularly different serotonin receptors and multiple, discrete neuronal and nonneuronal (includingendocrine) pathways and mechanisms that mediate the many functions ofserotonin. Nonetheless, gaps remain regarding aspects of the anatomy and physiology of serotonin in its roles as a neurotransmitter, a neuromodulator, and a hormone. Few serotonin receptor-selective drugs are available for clinical use. A group of selective serotonin reuptake inhibitors (SSRIs) remain the agents with greatest therapeutic utility, although the mechanisms underlying their delayed efficacy, which clearly result from adaptive consequences following repeated administrationrather than early uptake inhibition of serotonin by itself, are incompletely understood and appear to involve changes in signal transduction and gene expression in serotonergic and other neurotransmitter systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:04:37