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Titolo:
1-[CARBON-11]-GLUCOSE RADIATION-DOSIMETRY AND DISTRIBUTION IN HUMAN IMAGING STUDIES
Autore:
GRAHAM MM; PETERSON LM; MUZI M; GRAHAM BB; SPENCE AM; LINK JM; KROHN KA;
Indirizzi:
UNIV WASHINGTON,DEPT RADIOL NUCL MED,MAIL STOP 356113 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT RADIOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT RADIAT ONCOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT NEUROL SEATTLE WA 98195
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 39, anno: 1998,
pagine: 1805 - 1810
SICI:
0161-5505(1998)39:10<1805:1RADIH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; SCHIZOPHRENIA; PET;
Keywords:
C-11; GLUCOSE; DOSIMETRY; MONTE-CARLO SIMULATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Graham et al., "1-[CARBON-11]-GLUCOSE RADIATION-DOSIMETRY AND DISTRIBUTION IN HUMAN IMAGING STUDIES", The Journal of nuclear medicine, 39(10), 1998, pp. 1805-1810

Abstract

l-[Carbon-11]-D-glucose ([C-11]-glucose) is an important imaging agent for PET studies that have been used to study the normal brain, encephalitis, epilepsy, manic-depressive disorder, schizophrenia and brain tumors. Methods: Dosimetry estimates were calculated in subjects undergoing imaging studies to help define the radiation risk of [(11C)]-glucose PET imaging. Time-dependent radioactivity concentrations in normal tissues in 33 subjects after intravenous injection of [C-11]-glucosewere obtained by PET imaging. Radiation absorbed doses were calculated according to the procedures of the Medical Internal Radiation Dose (MIRD) committee along with the variation in dose based on the calculated standard deviation of activity distribution seen in the individual patients. Results: Total body exposure was a median of 3.0 mu Gy/MBq in men and 3.8 mu Gy/MBq in women. The effective dose equivalent was 3.8 mu Gy/MBq in men and 4.8 mu Gy/MBq in women. The critical organs were those that typically take up the most glucose (brain, heart wall andliver). Conclusion: The organ doses reported here are small and comparable to those associated with other commonly performed nuclear medicine tests and indicate that potential radiation risks associated with this radiotracer are within generally accepted limits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:34:01