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Titolo:
NITROGEN-13-AMMONIA AND OXYGEN-15-WATER ESTIMATES OF ABSOLUTE MYOCARDIAL PERFUSION IN LEFT-VENTRICULAR ISCHEMIC DYSFUNCTION
Autore:
GERBER BL; MELIN JA; BOL A; LABAR D; COGNEAU M; MICHEL C; VANOVERSCHELDE JLJ;
Indirizzi:
CLIN UNIV ST LUC,DIV CARDIOL,AVE HIPPOCRATE 10 2881 B-1200 BRUSSELS BELGIUM UNIV LOUVAIN,SCH MED,DIV CARDIOL BRUSSELS BELGIUM UNIV LOUVAIN,SCH MED,POSITRON EMISS TOMOG LAB BRUSSELS BELGIUM UNIV LOUVAIN,SCH MED,DIV CARDIOL LOUVAIN BELGIUM UNIV LOUVAIN,SCH MED,POSITRON EMISS TOMOG LAB LOUVAIN BELGIUM
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 10, volume: 39, anno: 1998,
pagine: 1655 - 1662
SICI:
0161-5505(1998)39:10<1655:NAOEOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; REGIONAL BLOOD-FLOW; N-13 AMMONIA; NONINVASIVE QUANTIFICATION; OXIDATIVE-METABOLISM; GLUCOSE-UTILIZATION; PET; HIBERNATION; INFARCTION;
Keywords:
MYOCARDIAL BLOOD FLOW; PET; MYOCARDIAL HIBERNATION; N-13 AMMONIA; O-15 WATER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Gerber et al., "NITROGEN-13-AMMONIA AND OXYGEN-15-WATER ESTIMATES OF ABSOLUTE MYOCARDIAL PERFUSION IN LEFT-VENTRICULAR ISCHEMIC DYSFUNCTION", The Journal of nuclear medicine, 39(10), 1998, pp. 1655-1662

Abstract

Measurements of resting myocardial blood flow (MBF) in patients with chronic left ventricular ischemic dysfunction by O-15-water with N-13-ammonia and PET have yielded conflicting results. The aim of this study was to perform a head-to-head comparison of both tracers in the samepatient population and to answer the question of whether distinctive tracer properties account for differences in estimates of MBF in chronically dysfunctional myocardium by both tracers. Methods: A total of 30 patients with chronic dysfunction of the anterior myocardial wall due to significant left anterior descending coronary artery disease underwent PET measurements of absolute MBF in the anterior wall by use of O-15-water and N-13- ammonia before coronary revascularization by either coronary artery bypass graft (n = 24) or percutaneous transluminal coronary angioplasty (n = 6), Improvement of regional contractile function was assessed by two-dimensional echocardiography at a mean of 7.5+/- 2.1 mo after revascularization. As judged from the changes in anterior myocardial wail motion after revascularization, patients were considered to have either reversibly (n = 16) or persistently (n = 14) dysfunctional myocardium. Estimates of MBF by O-15-water and N-13-ammonia, obtained in every patient before revascularization, were compared among the two patient groups by use of previously validated methods. Results: With N-13-ammonia, resting regional MBF was significantly higher in reversibly as opposed to persistently dysfunctional segments [84+/- 8 versus 48 +/- 6 ml (min.100 g)(-1), mean +/- s.e.m., p < 0.01]. By contrast, no such difference was found when using O-15-water to measure MBF [74 +/- 6 versus 86 +/- 9 ml (min.100 g)(-1), p = ns]. This was mainly due to the fact that the perfusable tissue fraction (PTF), a fitted parameter of the O-15-water model, was significantly higher in reversibly as opposed to persistently dysfunctional segments (0.63 +/- 0.03 versus 0.50 +/- 0.03, p < 0.05). As a consequence, the O-15-water perfusable tissue index (PTI), which is the ratio of the PTF to the anatomical tissue fraction, was greater in reversibly dysfunctional as opposed to persistently dysfunctional segments (1.07 +/- 0.07 versus 0.79 +/- 0.05, p < 0.01). Conclusion: This study demonstrates significant differences in MBF estimates between O-15-water and N-13-ammoniain chronically dysfunctional ischemic myocardium. Our results indicate that the O-15-water method yields higher absolute MBF values than the N-13-ammonia approach. Our results also support the use of PTI as a marker of myocardial tissue viability.

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Documento generato il 27/01/20 alle ore 01:18:07