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Titolo:
DIFFERENTIAL INTERLEUKIN-12 RESPONSIVENESS FOR INTERFERON-GAMMA PRODUCTION IN ADVANCED STAGES OF CANCER-PATIENTS CORRELATES WITH PERFORMANCE STATUS
Autore:
UNO K; SETOGUCHI J; TANIGAWA M; KISHI A; OGAWA M; SAOTOME H; FUJIWARA H; KISHIDA T;
Indirizzi:
LOUIS PASTEUR CTR MED RES,SAKYO KU,103-5 TANAKA MONZEN CHO KYOTO 6068225 JAPAN LOUIS PASTEUR CTR MED RES KYOTO 606 JAPAN OSAKA UNIV,SCH MED,BIOMED RES CTR SUITA OSAKA 565 JAPAN GENET INST INC CAMBRIDGE MA 02140
Titolo Testata:
Clinical cancer research
fascicolo: 10, volume: 4, anno: 1998,
pagine: 2425 - 2432
SICI:
1078-0432(1998)4:10<2425:DIRFIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; TUMOR-BEARING STATE; LYMPHOCYTE MATURATION FACTOR; ANTITUMOR T-CELLS; IFN-GAMMA; REGULATORY MECHANISMS; ENHANCED PRODUCTION; PROGNOSTIC FACTORS; NECROSIS-FACTOR; FACTOR NKSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K. Uno et al., "DIFFERENTIAL INTERLEUKIN-12 RESPONSIVENESS FOR INTERFERON-GAMMA PRODUCTION IN ADVANCED STAGES OF CANCER-PATIENTS CORRELATES WITH PERFORMANCE STATUS", Clinical cancer research, 4(10), 1998, pp. 2425-2432

Abstract

Interleukin 12 (IL-12) has been shown to exhibit potent antitumor activity in murine tumor models through various mechanisms including the capacity to stimulate IFN-gamma production by T cells and natural killer cells. The aim of the present study was to examine the efficacy of IL-12 in inducing IFN-gamma secretion in cancer patients. A comparisonwas made between healthy individuals who served as controls and cancer patients for IFN-gamma production induced after the stimulation of whole blood samples with 1000 pg/ml IL-12, Samples from all healthy individuals showed positive IL-12 responsiveness. Approximately half of the samples from patients displayed levels of IFN-gamma production comparable to those observed for controls, whereas the rest of the samplesexhibited almost-null responses. The incidences for reduced capacity of IFN-gamma production and null IL-12 responsiveness in cancer patients at all cancer stages or at a given advanced stage (stage IV) increased along with performance status. However, these correlated with neither the number of lymphocytes contained in the blood samples nor the tumor types. When peripheral blood mononuclear cells were isolated frompatient blood samples showing null/marginal responses, and their responsiveness was examined, 7 of 13 samples exhibited positive responses. Whereas enhanced tumor necrosis factor alpha production was also observed in some patients after IL-12 stimulation, the elevation of tumor necrosis factor alpha was induced only in blood samples that showed IL-12-stimulated IFN-gamma production. These observations indicate that a remarkable difference exists in IL-12 reactivity among cancer patients, and that differential IL-12 responsiveness depends largely on performance status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:49:11