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Titolo:
ATTACHMENT OF NONTYPABLE HAEMOPHILUS-INFLUENZAE TO HUMAN PHARYNGEAL EPITHELIAL-CELLS MEDIATED BY A GANGLIOSIDE RECEPTOR
Autore:
KAWAKAMI K; AHMED K; UTSUNOMIYA Y; RIKITOMI N; HORI A; OISHI K; NAGATAKE T;
Indirizzi:
NAGASAKI UNIV,INST TROP MED,DEPT INTERNAL MED,1-12-4 SAKAMOTO NAGASAKI 8528523 JAPAN NAGASAKI UNIV,INST TROP MED,DEPT INTERNAL MED NAGASAKI 8528102 JAPAN
Titolo Testata:
Microbiology and immunology
fascicolo: 10, volume: 42, anno: 1998,
pagine: 697 - 702
SICI:
0385-5600(1998)42:10<697:AONHTH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILUS-INFLUENZAE; RESPIRATORY-TRACT; ADHERENCE; ADHESION; PROTEINS; GLYCOSPHINGOLIPIDS; CATARRHALIS; PNEUMONIA; BINDING;
Keywords:
HAEMOPHILUS INFLUENZAE; GANGLIOSIDE; ATTACHMENT; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Kawakami et al., "ATTACHMENT OF NONTYPABLE HAEMOPHILUS-INFLUENZAE TO HUMAN PHARYNGEAL EPITHELIAL-CELLS MEDIATED BY A GANGLIOSIDE RECEPTOR", Microbiology and immunology, 42(10), 1998, pp. 697-702

Abstract

Nontypable Haemophilus influenzae (NTHI) is one of the major pathogens of human respiratory infections and has the ability to attach to pharyngeal epithelial cells, We characterized the epithelial cell receptor to which NTHI bind. Neuraminidase pretreatment of pharyngeal epithelial cells resulted in a significant decrease in NTHI attachment, suggesting sialic acid as an important component of the receptor, The attachment was not decreased in NTHI pretreated with 1,000 mu g/ml of fucose, N-acetyl-neuraminic acid, N-acetyl-glucosamine, N-acetyl-galactosamine, acetyl-salicylic acid and colominic acid. Only treatment with gangliosides D1a, D1b and D2 at a concentration of 12.5 mu g/ml significantly decreased the attachment. On the other hand, treatment with gangliosides M1, M2, M3, D3, T1b and asialoganglioside M1 did not decrease the attachment of NTHI, Only ganglioside D2 inhibited the attachment significantly at a concentration of 12.5 ng/ml, Other isolates of NTHI showed a decrease in attachment after treatment with ganglioside D2, Treatment of cells with anti-human GD2 monoclonal antibody also decreased the attachment of NTHI in a dose-dependent manner, This study indicates that sialic acid glycoconjugate, GD2, is one of the receptors of NTHI on human pharyngeal epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:50:31