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Titolo:
OXIDIZED LDL AND MALONDIALDEHYDE-MODIFIED LDL IN PATIENTS WITH ACUTE CORONARY SYNDROMES AND STABLE CORONARY-ARTERY DISEASE
Autore:
HOLVOET P; VANHAECKE J; JANSSENS S; VANDEWERF F; COLLEN D;
Indirizzi:
CATHOLIC UNIV LOUVAIN,CTR MOL & VASC BIOL,CAMPUS GASTHUISBERG,O&N,HERESTR 49 B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LOUVAIN,DEPT CARDIOL B-3000 LOUVAIN BELGIUM
Titolo Testata:
Circulation
fascicolo: 15, volume: 98, anno: 1998,
pagine: 1487 - 1494
SICI:
0009-7322(1998)98:15<1487:OLAMLI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN ATHEROSCLEROTIC PLAQUES; HUMAN MONOCYTE-MACROPHAGES; OXIDATIVE MODIFICATION; ENDOTHELIAL-CELLS; LIPID-PEROXIDATION; FOAM CELLS; IN-VITRO; PHOSPHOLIPIDS; ATHEROGENESIS;
Keywords:
LIPOPROTEINS; CORONARY DISEASE; ANGINA; DIAGNOSIS; PLAQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P. Holvoet et al., "OXIDIZED LDL AND MALONDIALDEHYDE-MODIFIED LDL IN PATIENTS WITH ACUTE CORONARY SYNDROMES AND STABLE CORONARY-ARTERY DISEASE", Circulation, 98(15), 1998, pp. 1487-1494

Abstract

Background - The association between oxidative modifications of LDL and coronary artery disease (CAD) is suspected but not established. Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stableCAD was investigated. Methods and Results - The study population contained 63 patients with acute coronary syndromes (45 with acute myocardial infarction and 18 with unstable angina pectoris), 35 nontransplanted patients with angiographically confirmed stable angina, 28 heart transplant patients with posttransplant CAD, 79 heart transplant patients without CAD, and 65 control subjects. After correction for age, sex,and LDL and HDL cholesterol, plasma levels of oxidized LDL and MDA-modified LDL were significantly higher in patients with CAD than in individuals without CAD (r(2) = 0.57 and r(2) = 0.26, respectively; both P= 0.0001). Plasma levels of MDA-modified LDL were significantly higher in patients with acute coronary syndromes than in individuals with stable CAD (r(2) = 0.65; P = 0.0001) and were associated with increasedlevels of troponin I and C-reactive protein (r(2) = 0.39 and r(2) = 0.34, respectively; both P = 0.0001), Plasma levels of oxidized LDL were not associated with increased levels of troponin I and C-reactive protein (r(2) = 0.089 and r(2) = 0.063, respectively). Conclusions - Elevated plasma levels of oxidized LDL are associated with CAD. Elevated plasma levels of MDA-modified LDL suggest plaque instability and may be useful for the identification of patients with acute coronary syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 13:13:48