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Titolo:
INFLUENZA-VIRUS RESISTANCE TO NEURAMINIDASE INHIBITORS
Autore:
MENDEL DB; SIDWELL RW;
Indirizzi:
GILEAD SCI INC,333 LAKESIDE DR FOSTER CITY CA 94404 UTAH STATE UNIV,INST ANTIVIRAL RES LOGAN UT 00000
Titolo Testata:
DRUG RESISTANCE UPDATES
fascicolo: 3, volume: 1, anno: 1998,
pagine: 184 - 189
SICI:
1368-7646(1998)1:3<184:IRTNI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GG167 ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC; SIALIC-ACID; IN-VITRO; DECREASED SENSITIVITY; ACTIVE-SITE; 4-GUANIDINO-NEU5AC2EN; REPLICATION; COMPLEX; GENERATION; INFECTIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Mendel e R.W. Sidwell, "INFLUENZA-VIRUS RESISTANCE TO NEURAMINIDASE INHIBITORS", DRUG RESISTANCE UPDATES, 1(3), 1998, pp. 184-189

Abstract

The recent reports from Hong Kong of an avian influenza virus which caused the death of six people has served to remind us of the constant threat of pandemics posed by influenza. Recently, structure-based drugdesign has resulted in the discovery of a new class of antiviral agents which specifically target the influenza virus neuraminidase. Two neuraminidase inhibitors are currently undergoing clinical evaluation for the prevention and treatment of influenza virus infection in man. Here we review the results of in vitro and in vivo studies relating to the potential development of resistance to this new class of compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:04:55