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Titolo:
EFFECTS OF LESIONS OF THE SUBSTANTIA INNOMINATA VENTRA PALLIDUM, GLOBUS-PALLIDUS AND MEDIAL SEPTUM ON RATS PERFORMANCE IN OBJECT-RECOGNITION AND RADIAL-MAZE TASKS - PHYSOSTIGMINE AND AMPHETAMINE TREATMENTS
Autore:
ENNACEUR A;
Indirizzi:
UNIV DURHAM,DEPT PSYCHOL,SCI LABS,SOUTH RD DURHAM DH1 3LE ENGLAND
Titolo Testata:
Pharmacological research
fascicolo: 4, volume: 38, anno: 1998,
pagine: 251 - 263
SICI:
1043-6618(1998)38:4<251:EOLOTS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; FOREBRAIN CHOLINERGIC SYSTEM; CONDITIONAL VISUAL-DISCRIMINATION; SIMILAR MEMORY IMPAIRMENTS; IBOTENIC-ACID LESIONS; EXCITOTOXIC LESIONS; ALZHEIMERS-DISEASE; WORKING MEMORY; GABAERGIC MARKERS; FIMBRIA-FORNIX;
Keywords:
LEARNING; MEMORY; MEDIAL SEPTUM; MEYNERT; NUCLEUS BASALIS MAGNOCELLULARIS; GLOBUS PALLIDUS; AMPHETAMINE; PHYSOSTIGMINE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
A. Ennaceur, "EFFECTS OF LESIONS OF THE SUBSTANTIA INNOMINATA VENTRA PALLIDUM, GLOBUS-PALLIDUS AND MEDIAL SEPTUM ON RATS PERFORMANCE IN OBJECT-RECOGNITION AND RADIAL-MAZE TASKS - PHYSOSTIGMINE AND AMPHETAMINE TREATMENTS", Pharmacological research, 38(4), 1998, pp. 251-263

Abstract

The present study examined the effects of electrolytic lesions of theMedial Septum/Vertical Diagonal Band of Broca (MS/VDBB), the Globus Pallidus (GP) and the Substantia-Innominata/Ventral Pallidum (SI/VP) onthe performance of rats in object-recognition memory and radial-maze learning tests. In the latter test, subgroups of sham-operated, MS/VDBB, SI/VP and GP rats were treated with saline, amphetamine or physostigmine. (1) In the object recognition task, the level of discriminationwas significantly lower in GP compared to SI/VP and in both GP and SI/VP compared to Control and MS/VDBB groups, however, only GP did not discriminate between new and familiar objects; (2) in the radial-maze task, GP and SI/VP lesions produced weak and transient impairment whereas MS/VDBB lesions produced a large deficit; (3) in the radial-maze task, performance of normal rats was improved with physostigmine and impaired with amphetamine. The effect of amphetamine was significant on non-memory measures only; (4) neither amphetamine nor physostigmine improved memory performances of lesioned rats. These results suggest thatthe septo-hippocampal projections are involved in spatial memory but not in object recognition whereas the integrity of Substantia Innominata/Ventral Pallidum does not seem critical for either task. The cholinergic nature of the deficit produced by the medial septal lesion remains in question because of improvements seen in sham-operated rats but not in lesioned rats. (C) 1998 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:20:52