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Titolo:
THE ANALGESIC EFFECTS OF TRYPTOPHAN AND ITS METABOLITES IN THE RAT
Autore:
HEYLIGER SO; GOODMAN CB; NGONG JM; SOLIMAN KFA;
Indirizzi:
FLORIDA A&M UNIV,COLL PHARM & PHARMACEUT SCI TALLAHASSEE FL 32307 FLORIDA A&M UNIV,COLL PHARM & PHARMACEUT SCI TALLAHASSEE FL 32307
Titolo Testata:
Pharmacological research
fascicolo: 4, volume: 38, anno: 1998,
pagine: 243 - 250
SICI:
1043-6618(1998)38:4<243:TAEOTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITOTOXIN QUINOLINIC ACID; KYNURENIC ACID; BRAIN; SEROTONIN; BLOOD; 5-HYDROXYKYNURAMINE; RECEPTORS; TRANSPORT; MICE;
Keywords:
KYNURENINE; QUINOLINIC ACID; KYNURENIC ACID; ANALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.O. Heyliger et al., "THE ANALGESIC EFFECTS OF TRYPTOPHAN AND ITS METABOLITES IN THE RAT", Pharmacological research, 38(4), 1998, pp. 243-250

Abstract

Male Sprague-Dawley rats weighing 150-200 g were given doses of tryptophan methyl ester or its metabolites; kynurenine sulphate, kynurenic acid, xanthurenic acid, quinolinic acid, anthranilic acid methyl esteror picolinic acid methyl ester. Doses administered intraperitoneally were 50, 100, 200, 300, 400 and 600 mg kg(-1). Pain sensitivity was assessed using the hotplate and tailflick methods at 30 min before: and at 30-min interval after the injection of test compounds. The administrations of tryptophan, kynurenic acid, quinolinic acid, anthranilic acid, xanthurenic acid, picolinic acid, and kynurenine were associated with analgesia. Animals given 300 or 600 mg kg(-1) of tryptophan exhibited a significant decrease (P < 0.05; P < 0.01, respectively) in pain sensitivity with the hotplate test. L-Kynurenic acid (300 mg kg(-1)) produced analgesia (P < 0.01) 30 min after drug administration. Quinolinic and anthranilic acids both produced prolonged decrease in pain sensitivity (P < 0.05); using the tailflick test. These results indicate that tryptophan and some of its metabolites possess analgesic properties. (C) 1998 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:47:03