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Titolo:
CHANGES IN THE MORPHOLOGY AND COMPONENTS OF THE CORONARY-ARTERIES DURING THE PROGRESSION OF CORONARY ARTERIOSCLEROSIS FOLLOWING CARDIAC TRANSPLANTATION IN RATS
Autore:
HAMANO K; ITO H; FUJIMURA Y; TSUBOI H; ESATO K;
Indirizzi:
YAMAGUCHI UNIV,SCH MED,DEPT SURG 1 UBE YAMAGUCHI 755 JAPAN
Titolo Testata:
Cardiovascular surgery
fascicolo: 3, volume: 6, anno: 1998,
pagine: 296 - 301
SICI:
0967-2109(1998)6:3<296:CITMAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAFT ARTERIOSCLEROSIS; CHRONIC REJECTION; MODEL; HEART; ATHEROSCLEROSIS; ALLOGRAFTS; DISEASE;
Keywords:
RAT; HEART TRANSPLANTATION; ARTERIOSCLEROSIS; CORONARY ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Hamano et al., "CHANGES IN THE MORPHOLOGY AND COMPONENTS OF THE CORONARY-ARTERIES DURING THE PROGRESSION OF CORONARY ARTERIOSCLEROSIS FOLLOWING CARDIAC TRANSPLANTATION IN RATS", Cardiovascular surgery, 6(3), 1998, pp. 296-301

Abstract

In order to examine the changes in coronary artery morphology following cardiac transplantation, the intimal and medial areas and vascular components were measured 30 and 60 days postoperatively in rats receiving both iso- (n = 5, each time) and allotransplantations (n = 7, eachtime), Although cyclosporine A was administered intramuscularly (10 mg/kg per day) for 20 days following transplantation, graft rejection progressed gradually in the allotransplanted group. There were no clearchanges in the intimal or medial areas following transplantation in the isotransplanted group. The intimal area of the coronary arteries inthe allograft group was significantly thicker 30 and 60 days following transplantation, while the medial area of the coronary arteries in this group was significantly thinner than that of the isotransplantation group at these same time points. In the thickened intimal areas in the allotransplantation group, only the density of smooth muscle cells was higher following transplantation. In the thinned medial areas in the allotransplantation group, the densities of the smooth muscle cellsand collagen were less than those in the isotransplantation group. These changes suggest that following transplantation, smooth muscle cells proliferate in the intimal areas, while smooth muscle cells and collagen are degraded in the medial areas. (C) 1998 The International Society for Cardiovascular Surgery. Published by Elsevier Science Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:11:37