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Titolo:
PHYSIOLOGICAL-CHARACTERISTICS OF SEROTONIN TRANSPORTERS ON RAT PLATELETS
Autore:
CICINSAIN L; FROBE A; JERNEJ B;
Indirizzi:
RUDJER BOSKOVIC INST,LAB NEUROCHEM & MOL NEUROBIOL,BIJENICKA CESTA 54HR-10000 ZAGREB CROATIA
Titolo Testata:
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
fascicolo: 4, volume: 120, anno: 1998,
pagine: 723 - 729
SICI:
1095-6433(1998)120:4<723:POSTOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3-IMIPRAMINE BINDING; SEASONAL-VARIATION; AGE; LEVEL;
Keywords:
5-HT TRANSPORTER; PLATELETS; PHYSIOLOGY; SEROTONIN UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L. Cicinsain et al., "PHYSIOLOGICAL-CHARACTERISTICS OF SEROTONIN TRANSPORTERS ON RAT PLATELETS", Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 120(4), 1998, pp. 723-729

Abstract

Physiological characteristics of serotonin (5-hydroxytryptamine, 5HT)transport through the platelet membrane was investigated in Wistar rats with our recently developed method permitting repetitive measurements of transporter kinetics in individual animals. Full kinetic analysis in the population of 91 animals revealed Michaelis constant (K-m) of0.158 +/- 0.025 mu M and maximal velocity (V-max) of 5HT uptake of 225 +/- 32 pmol per 10(8)platelets min(-1) (mean +/- S.D.). Both kineticparameters demonstrated normal distribution curves, which for V-max were slightly skevied toward higher than average values. No gender effect was shown in frequency distributions, mean values and variability of kinetic parameters. A significant intraindividual correlation between kinetic parameters was found suggesting compensation at the level ofthe plasma membrane. Kinetic parameters were not influenced by age (until the middle age) or annual cycle (under laboratory conditions) andwere shown to be fairly stable in time, supporting the view that platelet 5HT transport kinetics could be a useful biological trait marker. (C) 1998 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:46:23