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Titolo:
Protective effects of type I and type II interferons toward Rous sarcoma virus-induced tumors in chickens
Autore:
Plachy, J; Weining, KC; Kremmer, E; Puehler, F; Hala, K; Kaspers, B; Staeheli, P;
Indirizzi:
Acad Sci Czech Republ, Inst Mol Genet, CR-16637 Prague 6, Czech Republic Acad Sci Czech Republ Prague Czech Republic 6 7 Prague 6, Czech Republic Univ Freiburg, Dept Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany Univ Munich, Inst Anim Physiol, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 Anim Physiol, D-80539 Munich, Germany GSF, Inst Mol Immunol, D-81377 Munich, Germany GSF Munich Germany D-81377 SF, Inst Mol Immunol, D-81377 Munich, Germany Innsbruck Univ, Inst Gen & Expt Pathol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 athol, A-6020 Innsbruck, Austria
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 256, anno: 1999,
pagine: 85 - 91
SICI:
0042-6822(19990330)256:1<85:PEOTIA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
V-SRC; TRANSFORMING VIRUSES; GAMMA; GENE; MHC; EXPRESSION; IMMUNITY; CLONING; COMPLEX; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiburg, Dept Virol, Hermann Herder Str 11, D-79104 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79104
Citazione:
J. Plachy et al., "Protective effects of type I and type II interferons toward Rous sarcoma virus-induced tumors in chickens", VIROLOGY, 256(1), 1999, pp. 85-91

Abstract

Growth of tumors induced by Rous sarcoma virus (RSV) is controlled by alleles at the major histocompatibility complex locus in chickens, indicating that immunological host defense mechanisms play a major role. We show here that the resistance phenotype of CB regressor chickens can be partially reverted by treating the animals with a monoclonal antibody that neutralizes the major serotype of chicken type 1 interferon, ChIFN-alpha. Injection of recombinant ChIFN-alpha into susceptible CC progressor chickens resulted in adose-dependent inhibition of RSV-induced tumor development. This treatmentwas not effective, however, in CC chickens challenged with a DNA constructexpressing the v-src oncogene, suggesting that the beneficial effect of type 1 interferon in this system resulted from its intrinsic antiviral activity and probably not from indirect immunmodulatory effects. By contrast, recombinant chicken interferon-gamma strongly inhibited tumor growth when given to CC chickens that were challenged with the v-src oncogene, indicating that the two cytokines target different steps of tumor development. (C) 1999Academic Press.

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Documento generato il 28/01/20 alle ore 14:47:45