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Titolo:
Reversible congestive heart failure caused by myocardial hibernation
Autore:
Wilson, JM;
Indirizzi:
St77030s Episcopal Hosp, Texas Heart Inst, Dept Adult Cardiol, Houston, TXSt Lukes Episcopal Hosp Houston TX USA 77030 t Adult Cardiol, Houston, TX
Titolo Testata:
TEXAS HEART INSTITUTE JOURNAL
fascicolo: 1, volume: 26, anno: 1999,
pagine: 19 - 27
SICI:
0730-2347(1999)26:1<19:RCHFCB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR DYSFUNCTION; POSITRON-EMISSION-TOMOGRAPHY; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; REDISTRIBUTION TL-201 TOMOGRAPHY; VIABLE MYOCARDIUM; PREDICTING RECOVERY; COMPUTED-TOMOGRAPHY; POSTREVASCULARIZATION RECOVERY; SURGICAL REVASCULARIZATION;
Keywords:
angioplasty; coronary disease; deoxyglucose diagnostic use; dobutamine diagnostic use; fluorine radioisotopes diagnostic use; myocardial hibernation; myocardial ischemia; myocardial revascularization; myocardial stunning; technetium Tc 99m sestamibi diagnostic use; thallium radioisotopes diagnostic use; ventricular dysfunction; left etiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, JM 6624 Fannin St,Suite 2480, Houston, TX 77030 USA 6624 Fannin St,Suite 2480 Houston TX USA 77030 n, TX 77030 USA
Citazione:
J.M. Wilson, "Reversible congestive heart failure caused by myocardial hibernation", TEX HEART I, 26(1), 1999, pp. 19-27

Abstract

Myocardial hibernation is reversible contractile dysfunction of cardiac myocytes caused by chronic ischemia. Animal studies and observations in humanbeings suggest that the term hibernation is a misnomer Repetitive ischemicinsult that does not produce necrosis results in functional and histologictissue deterioration, which culminates in myocyte apoptosis. Revascularization of "hibernating " myocardium results in partial or complete recovery of function, depending upon the duration of ischemia and the severity of cellular degeneration, improvement in global left ventricular function is proportional to the quantity of hibernating tissue that is revascularized, but this threshold quantity has not been determined with certainty. Diagnostic methods used to detect viable tissue within akinetic left ventricular segments depend upon the recognition of recruitable contractile function or the active concentration of a radioactive tracer No diagnostic method has shown clear superiority The most sensitive methods appear to be single-photon emission computed tomographic imaging after reinjection of thallium-201 at 24 hours and positron-emission tomographic imaging with F-18-fluorodeoxyglucose. The most specific diagnostic method appears to be measurement of dobutamine-stimulated contractile function, using either echocardiography or gated magnetic resonance imaging. We present a review of the pathophysiology, diagnosis, and treatment of myocardial hibernation, and include an illustrative case report involving a 57-year-old man with myocardial hibernation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:24:25