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Titolo:
Plasma serotonin level after 1 day of fluoxetine treatment: a biological predictor for antidepressant response?
Autore:
Alvarez, JC; Gluck, N; Fallet, A; Gregoire, A; Chevalier, JF; Advenier, C; Spreux-Varoquaux, O;
Indirizzi:
Univ Paris 05, Fac Med Paris Ouest, F-78150 Le Chesnay, France Univ Paris 05 Le Chesnay France F-78150 uest, F-78150 Le Chesnay, France HopLe Midnot, Dept Biochim Pharmacol Toxicol, Ctr Hosp Versailles, F-78150Hop A Midnot Le Chesnay France F-78150 col, Ctr Hosp Versailles, F-78150 Univ Paris 05, Fac Med Paris Ouest, F-78000 Versailles, France Univ Paris 05 Versailles France F-78000 uest, F-78000 Versailles, France Hop Richaud, Psychiat Serv, Ctr Hosp Versailles, F-78000 Versailles, France Hop Richaud Versailles France F-78000 ailles, F-78000 Versailles, France
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 143, anno: 1999,
pagine: 97 - 101
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; H-3 IMIPRAMINE BINDING; CLINICAL IMPROVEMENT; PLATELET SEROTONIN; DRUG; BLOOD; CLOMIPRAMINE; NORFLUOXETINE; INCREASE; SERUM;
Keywords:
fluoxetine and norfluoxetine; major depressive episode; plasma 5-HT; serum 5-HT; biological predictor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Alvarez, JC Univ Paris 05, Fac Med Paris Ouest, 177 Rue Versailles, F-78150 Le Chesnay, Univ Paris 05 177 Rue Versailles Le Chesnay France F-78150 y,
Citazione:
J.C. Alvarez et al., "Plasma serotonin level after 1 day of fluoxetine treatment: a biological predictor for antidepressant response?", PSYCHOPHAR, 143(1), 1999, pp. 97-101

Abstract

Rationale: Antidepressant treatments present a delayed onset of action. Objective: The present study investigated whether plasma or serum serotonin, 5-hydroxytryptamine (5-HT), could predict clinical improvement. Methods: Biological parameters were determined after a 4-week drug-free period (day 0)and 1, 14 and 28 days after the beginning of the treatment with fluoxetine20 mg daily in depressed patients. Clinical evaluations were assessed on days 0, 14 and 28. Results: One day after a single dose, the mean values of plasma 5-HT (5.4 +/- 2.6 nmol/l) and serum 5-HT (484 +/- 215 nmol/l) were not statistically different from basal mean values (4.5 +/- 2.5 nmol/l and 523 +/- 263 nmol/l, respectively). The repeated treatment significantly reduced serum 5-HT to 34% (P = 0.002) and 17% (P = 0.0004) of pretreatment values after 14 and 28 days of treatment, respectively; plasma 5-HT was also reduced significantly to 28% and 15% of pretreatment values (P < 0.05 in bothcases). At day 28, four of the eight patients responded by showing a reduction in MADRS score of at least 50 % of the baseline score. No correlation was found between pretreatment values of serum or plasma 5-HT and clinical evolution, even if a tendency (P < 0.07) to lower serum 5-HT pretreatment values was observed in responders. Plasma 5-HT after 1 day of treatment was significantly different between responders and non-responders: the plasma 5-HT concentration in responders was 3.4 +/- 1.7 nmol/l versus 7.4 +/- 1.6 nmol/l in non-responders (P = 0.02). Moreover, plasma 5-HT levels after 1 day of treatment were positively correlated to the final MADRS score (r = +0.89, n = 8, P = 0.003) and inversely correlated to its change from the initial score (r = -0.76, n = 8, P = 0.02). Conclusion. These preliminary data show that fluoxetine and norfluoxetine might influence 5-HT peripheral venous blood parameters and that plasma 5-HT after 1 day of treatment might be abiological predictor for antidepressant response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 22:00:07