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Titolo:
Assessment of neuroleptic-like properties of progesterone
Autore:
Rupprecht, R; Koch, M; Montkowski, A; Lancel, M; Faulhaber, J; Harting, J; Spanagel, R;
Indirizzi:
Univ Munich, Dept Psychiat, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 ept Psychiat, D-80336 Munich, Germany Merk KGaA, Dept CNS Res, D-64271 Darmstadt, Germany Merk KGaA Darmstadt Germany D-64271 CNS Res, D-64271 Darmstadt, Germany Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany Max Planck Inst Psychiat, Inst Clin, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 143, anno: 1999,
pagine: 29 - 38
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROACTIVE STEROIDS; ANTIPSYCHOTIC-DRUGS; PREPULSE INHIBITION; CORPUS STRIATUM; RECEPTOR; RATS; BRAIN; NEUROSTEROIDS; APOMORPHINE; ALLOPREGNANOLONE;
Keywords:
progesterone; neuroleptic; psychosis; neurosteroids; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Rupprecht, R Univ Munich, Dept Psychiat, Nussbaumstr 7, D-80336 Munich, Germany Univ Munich Nussbaumstr 7 Munich Germany D-80336 ch, Germany
Citazione:
R. Rupprecht et al., "Assessment of neuroleptic-like properties of progesterone", PSYCHOPHAR, 143(1), 1999, pp. 29-38

Abstract

There is considerable evidence from epidemiological studies that the onsetof psychiatric disorders may be related to changes in the secretion of gonadal hormones. For example, the postpartum period appears to be a vulnerable phase for the occurrence of psychiatric disturbances such as dysphoric mood and even severe psychotic disturbances. It has been suggested that a sudden drop in progesterone concentrations may contribute to the development of such disorders. Because the administration of this steroid might be of therapeutic value in psychiatric disturbances, we investigated the behavioralproperties of progesterone in the rat to assess putative neuroleptic-like properties of this steroid. Progesterone administration dose-dependently increased the EEG activity during wakefulness in the 10- to 30-Hz frequency bands and decreased locomotor activity. While no anxiolytic activity could be detected in the plus maze, the highest dose of progesterone (90 mg/kg) exerted an inhibitory effect on the conditioned avoidance response. In contrast to haloperidol (0.5 mg/kg), progesterone neither produced catalepsy nor antagonized amphetamine-induced stereotypy. However, both progesterone (10,30 and 90 mg/kg) and haloperidol (0.1 mg/kg) effectively restored the disruption of the prepulse inhibition (PPI) of the acoustic startle response (ASR) that was evoked by apomorphine (2 mg/kg). In contrast, allopregnanolone(10 mg/kg), one of the main metabolites of progesterone, did not significantly antagonize the effect of apomorphine on the PPI. This behavioral profile of progesterone is compatible with the sedative properties of its metabolite allopregnanolone via the GABA(A) receptor but also with the possibility that progesterone itself shares some properties with atypical antipsychotics, which may be relevant for the development and treatment of psychotic disturbances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:05:15