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Titolo:
l-Sulpiride, at a low, non neuroleptic dose, prevents conditioned fear stress induced freezing behavior in rats
Autore:
Cavazzuti, E; Bertolini, A; Vergoni, AV; Arletti, R; Poggioli, R; Forgione, A; Benelli, A;
Indirizzi:
Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy Univ Naples, Sch Med 1, Inst Pharmacol, Naples, Italy Univ Naples NaplesItaly ples, Sch Med 1, Inst Pharmacol, Naples, Italy
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 143, anno: 1999,
pagine: 20 - 23
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; PANIC DISORDER; DOUBLE-BLIND; EFFICACY; ANTIDEPRESSANTS; ANXIOLYTICS; CITALOPRAM; IMIPRAMINE; DEPRESSION; MODELS;
Keywords:
l-sulpiride; fluoxetine; freezing behavior; conditioned fear stress; anticipatory anxiety; panic behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Cavazzuti, E Univna,dena, Dept Biomed Sci, Pharmacol Sect, Via G Campi 287, I-41100 Mode Univ Modena Via G Campi 287 Modena Italy I-41100 -41100 Mode
Citazione:
E. Cavazzuti et al., "l-Sulpiride, at a low, non neuroleptic dose, prevents conditioned fear stress induced freezing behavior in rats", PSYCHOPHAR, 143(1), 1999, pp. 20-23

Abstract

Antidepressant drugs are effective in anxiety states, including panic disorder. Both clinical and animal studies indicate that l-sulpiride, at low, non-neuroleptic doses, has antidepressant activity. The present study examined the effect of an antidepressant dose of l-sulpiride (4 mg/kg per day SC), compared with a well-established antidepressant drug (fluoxetine, 3 mg/ kg per day SC), in a rat model of anticipatory anxiety/panic behavior: conditioned fear stress-induced freezing behavior. Long-term (26 days) administration of l-sulpiride almost completely abolished freezing, a similar effectbeing produced by fluoxetine (freezing duration, in seconds: controls, 148.1 +/- 29.6; l-sulpiride, 27.5 +/- 8.3; fluoxetine, 72.0 +/- 15.2), The same doses of l-sulpiride (4 mg/kg SC) and fluoxetine (3 mg/kg SC) had no effect when administered for shorter periods (1, 5, or 12 days). No effect was produced by the longterm (26 days) administration of a neuroleptic dose of l-sulpiride (20 mg/kg per day SC). These results demonstrate that long-termadministration of low, non-neuroleptic doses of l-sulpiride, is highly effective in an animal model of anticipatory anxiety/panic behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:31:43