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Titolo:
Pulmonary function at school-age in surfactant-treated preterm infants
Autore:
Gappa, M; Berner, MM; Hohenschild, S; Dammann, CEL; Bartmann, P;
Indirizzi:
Univnyannover, Childrens Hosp, Dept Pediat Pulm & Neonatol, Hannover, Germa Univ Hannover Hannover Germany Pediat Pulm & Neonatol, Hannover, Germa Univ Ulm, Childrens Hosp, Dept Pediat, Ulm, Germany Univ Ulm Ulm Germany niv Ulm, Childrens Hosp, Dept Pediat, Ulm, Germany Univ Hamburg, Childrens Hosp, Dept Pediat, Hamburg, Germany Univ Hamburg Hamburg Germany ldrens Hosp, Dept Pediat, Hamburg, Germany Univ Bonn, Dept Neonatol, Childrens Hosp, Bonn, Germany Univ Bonn Bonn Germany nn, Dept Neonatol, Childrens Hosp, Bonn, Germany
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 27, anno: 1999,
pagine: 191 - 198
SICI:
8755-6863(199903)27:3<191:PFASIS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; LONG-TERM SURVIVORS; BRONCHOPULMONARY DYSPLASIA; BOVINE SURFACTANT; BIRTH-WEIGHT; FOLLOW-UP; EXOGENOUS SURFACTANT; SYNTHETIC SURFACTANT; REPLACEMENT THERAPY;
Keywords:
surfactant; long-term outcome; respiratory function; lung volume; airway resistance; spirometry; randomized controlled clinical trial; prematurity; bronchopulmonary dysplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gappa, M Med Hsch Hannover, Kinderklin, D-30623 Hannover, Germany Med HschHannover Hannover Germany D-30623 23 Hannover, Germany
Citazione:
M. Gappa et al., "Pulmonary function at school-age in surfactant-treated preterm infants", PEDIAT PULM, 27(3), 1999, pp. 191-198

Abstract

A follow-up study was conducted in 40 children who had been enrolled in a prospective randomized study of exogenous surfactant therapy for respiratory distress syndrome (RDS) (n = 22; S) or placebo (n = 18; P) to determine long-term pulmonary sequelae of surfactant treatment in premature infants with RDS. At follow-up, mean (SD) age was 6.63 (0.18) and 6.55 (0.23) years for S and P, respectively. Complete lung function tests (LFT) were attemptedin all patients. Satisfactory data were obtained in 17/22 surfactant-treated and in 12/18 control children. There was no significant difference between groups for anyof the parameters measured. Mean (SD) functional residual capacity (FRC) was 92% (16%) and 90% (21%) predicted, mean (SD) airway resistance (R-aw,R-exp) was 122% (25%) and 127% (61%), and mean (SD) forced expiratory volume in 1 s (FEV1) was 104% (12%) and 99% (17%) predicted for S and P. Only maximal expiratory flow at 25% vital capacity (L/s) was significantly below the predicted range in S and P groups, with 74% (23%) and 77% (28%), respectively. To test bronchial hyperreactivity, a simple standardized running test was performed: 4 children in S and 5 in P showed a significant response as defined by clinical airway obstruction or changes in FEV1 and/or R-aw, with no significant difference between groups. Although we found no major abnormalities in lung function and no difference between S and P at early school-age, lack of cooperation during lung Function tests makes further follow-up necessary. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:01:34