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Titolo:
Cocaethylene synthesis in Drosophila
Autore:
Torres, G; Horowitz, JM;
Indirizzi:
SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Neurosci Program, Buffalo, NY 14260 USA Medaille Coll, Dept Psychol, Buffalo, NY 14214 USA Medaille Coll Buffalo NY USA 14214 l, Dept Psychol, Buffalo, NY 14214 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 263, anno: 1999,
pagine: 201 - 204
SICI:
0304-3940(19990326)263:2-3<201:CSID>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-DEHYDROGENASE; SEROTONIN TRANSPORTER; COCAINE; MELANOGASTER; ETHANOL; EXPRESSION; PHARMACOLOGY; METABOLITE; AFFINITY; CLONING;
Keywords:
ethanol; cocaine; esterases; evolution; addiction; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, G SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 rogram, Buffalo, NY 14260 USA
Citazione:
G. Torres e J.M. Horowitz, "Cocaethylene synthesis in Drosophila", NEUROSCI L, 263(2-3), 1999, pp. 201-204

Abstract

Cocaethylene is an active cocaine metabolite that targets mammalian neuralreward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which cocaine can be converted to cocaethylene, presumably viaethanol-sensitive enzymes. These findings illustrate the striking similarity or gene products in humans and flies, which might reflect a homologous role in the metabolic inactivation of cocaine. Further, this conservation ofmetabolic steps suggests that Drosophila can be used to study cellular, molecular and biochemical processes leading to polydrug abuse and addiction. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:55:48