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Titolo:
Decreased accumulation of endogenous brain-derived neurotrophic factor against constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed rats
Autore:
Mizisin, AP; DiStefano, PS; Liu, XC; Garrett, DN; Tonra, JR;
Indirizzi:
Univ Calif San Diego, Dept Pathol, Vet Adm Med Ctr, La Jolla, CA 92093 USAUniv Calif San Diego La Jolla CA USA 92093 ed Ctr, La Jolla, CA 92093 USA Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA Regeneron Pharmaceut Inc Tarrytown NY USA 10591 , Tarrytown, NY 10591 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 263, anno: 1999,
pagine: 149 - 152
SICI:
0304-3940(19990326)263:2-3<149:DAOEBN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; SENSORY NEURONS; PERIPHERAL-NERVE; MESSENGER-RNA; GROWTH-FACTOR; EXPRESSION; BDNF; MECHANISMS; RECEPTORS; AXOTOMY;
Keywords:
anterograde axonal transport; brain-derived neurotrophic factor; experimental diabetes; retrograde axonal transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Mizisin, AP Univ Calif San Diego, Dept Pathol, Vet Adm Med Ctr, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 olla, CA 92093 USA
Citazione:
A.P. Mizisin et al., "Decreased accumulation of endogenous brain-derived neurotrophic factor against constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed rats", NEUROSCI L, 263(2-3), 1999, pp. 149-152

Abstract

Anterograde and retrograde trafficking or brain-derived neurotrophic factor (BDNF) was examined in streptozotocin-diabetic and galactose-fed rats by measuring accumulation of endogenous neurotrophin proximal and distal to two constricting sciatic nerve ligatures and by direct injection of radiolabeled neurotrophin into the sciatic nerve. Compared to controls, accumulationof endogenous BDNF proximal and distal to the ligatures as well as basal levels in non-ligated nerve segments were decreased in streptozotocin-diabetic and galactose-fed rats. Neither streptozotocin diabetes nor galactose intoxication affected the amount of I-125-labeled BDNF retrogradely transported to the DRG after injection into the sciatic nerve. These results suggestthat reduced anterograde and retrograde accumulations of BDNF in experimental diabetes are not a result of impaired capacity for receptor-mediated transport. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:00:19