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Titolo:
(+)-alpha-[C-11]dihydro-tetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis
Autore:
Bohnen, NI; Albin, RL; Frey, KA; Fink, JK;
Indirizzi:
Univ Michigan, Sch Med, Dept Internal Med, Div Nucl Med, Ann Arbor, MI USAUniv Michigan Ann Arbor MI USA rnal Med, Div Nucl Med, Ann Arbor, MI USA Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA , Sch Med, Dept Neurol, Ann Arbor, MI USA Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI 48105 USA Vet Adm Med Ctr Ann Arbor MI USA 48105 uc & Clin, Ann Arbor, MI 48105 USA
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 52, anno: 1999,
pagine: 1067 - 1069
SICI:
0028-3878(19990323)52:5<1067:(PIIFP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER; PARKINSONS-DISEASE; CHROMOSOME 2Q;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Albin, RL Neurosci Lab Bldg,1103 E Huron, Ann Arbor, MI 48104 USA Neurosci Lab Bldg,1103 E Huron Ann Arbor MI USA 48104 48104 USA
Citazione:
N.I. Bohnen et al., "(+)-alpha-[C-11]dihydro-tetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis", NEUROLOGY, 52(5), 1999, pp. 1067-1069

Abstract

Clinical observations suggest a disturbance of striatal dopaminergic function in familial paroxysmal dystonic choreoathetosis (PDC). The authors usedPET with [C-11]dihydrotetrabenazine (DTBZ) to study striatal dopaminergic innervation in PDC. The results did not reveal abnormal DTBZ binding potential in PDC striatum. This suggests that dopaminergic abnormalities, if present, may be due to altered regulation of dopamine release or to postsynaptic mechanisms, rather than to an altered density of nigrostriatal innervation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:37:34