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Titolo:
Differential regulation of AP-1 DNA-binding activity by D1 and D2 dopaminereceptor antagonists in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle
Autore:
Kashihara, K; Akiyama, K; Ishihara, T; Manabe, Y; Abe, K;
Indirizzi:
Okayama Univ, Sch Med, Dept Neurol, Okayama 7000914, Japan Okayama Univ Okayama Japan 7000914 , Dept Neurol, Okayama 7000914, Japan Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 7000914, Japan Okayama Univ Okayama Japan 7000914 Neuropsychiat, Okayama 7000914, Japan
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 2, volume: 21, anno: 1999,
pagine: 175 - 179
SICI:
0161-6412(199903)21:2<175:DROADA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; STRIATOPALLIDAL NEURONS; PROTEINS; STRIATUM;
Keywords:
dopamine antagonist; SCH23390; sulpiride; AP-1; caudate-putamen; globus pallidus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kashihara, K Okayamaanniv, Sch Med, Dept Neurol, 2-5-1 Shikata-cho, Okayama 7000914, Jap Okayama Univ 2-5-1 Shikata-cho Okayama Japan 7000914 14, Jap
Citazione:
K. Kashihara et al., "Differential regulation of AP-1 DNA-binding activity by D1 and D2 dopaminereceptor antagonists in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medial forebrain bundle", NEUROL RES, 21(2), 1999, pp. 175-179

Abstract

The effect of D1 and D2 dopamine receptor antagonists on the DNA-binding activity of the AP-1 transcription factor was studied in the rat caudate-putamen and globus pallidus following a unilateral 6-OHDA lesion of the medialforebrain bundle. In the caudate-putamen, vehicle-treated rats showed increased AP-I DNA-binding activity, which appeared to be reversed completely by treatment with the D1 receptor antagonist SCH23390 (1 mg kg(-1) i.p.) andpartially by the D2 antagonist sulpiride (50 mg kg(-1) i.p.). In the globus pallidus, vehicle and sulpiride did not induce AP-1, while SCH23390 increased it significantly This induction was much more prominent in the 6-OHDA-lesioned hemisphere than in the intact hemisphere. The present study suggests that in the caudate-putamen, dopamine-depletion induces long-lasting enhancement of AP-1 DNA-binding activity via activation of D1 receptors and the simultaneous activation of D2 receptors facilitate it However, in the globus pallidus of the 6-OHDA-lesioned hemisphere, D1 but not D2 antagonism induces AP-1 in certain cell populations which may be distinct from those expressing AP-1 upon stimulation of D2 receptors.

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Documento generato il 05/04/20 alle ore 03:29:21