Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pentanucleotide repeat and size polymorphisms in the apolipoprotein(a) gene are associated with the lipoprotein(a) concentration in chronic hemodialysis patients
Autore:
Tanaka, M; Yanagi, H; Ando, R; Kurihara, S; Hirano, C; Kobayashi, K; Kikuchi, S; Hamaguchi, H; Tsuchiya, S; Tomura, S;
Indirizzi:
Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Clin Med, Tsukuba, Ibaraki 3058575, Japan Univ TsukubaTsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Nakano Gen Hosp, Dept Med, Tokyo, Japan Nakano Gen Hosp Tokyo JapanNakano Gen Hosp, Dept Med, Tokyo, Japan Kasukabe Shuwa Hosp, Dept Med, Kasukabe, Japan Kasukabe Shuwa Hosp Kasukabe Japan huwa Hosp, Dept Med, Kasukabe, Japan
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 81, anno: 1999,
pagine: 414 - 420
SICI:
0028-2766(199904)81:4<414:PRASPI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; CORONARY-ARTERY DISEASE; PLASMA-CONCENTRATIONS; LP(A) CONCENTRATIONS; DIABETES-MELLITUS; HEART-DISEASE; ISOFORM SIZE; ATHEROSCLEROSIS; PHENOTYPES; REGION;
Keywords:
lipoprotein(a); apolipoprotein(a); chronic hemodialysis; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Yanagi, H Univ,Tsukuba, Inst Community Med, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058575 Univ Tsukuba Tennoudai 1-1-1 Tsukuba Ibaraki Japan 3058575 58575
Citazione:
M. Tanaka et al., "Pentanucleotide repeat and size polymorphisms in the apolipoprotein(a) gene are associated with the lipoprotein(a) concentration in chronic hemodialysis patients", NEPHRON, 81(4), 1999, pp. 414-420

Abstract

The elevation of serum or plasma lipoprotein(a) [Lp(a)] levels is regardedas an independent risk factor for cardiovascular disease, and many previous reports demonstrated that Lp(a) levels in hemodialysis patients were significantly higher than in controls. The purpose of this study was to investigate the effect of a pentanucleotide repeat polymorphism [(TTTTA)n] in the 5'-flanking region of the apolipoprotein(a) [apo(a)] gene and of a size polymorphism of apo(a) for elevated Lp(a) concentrations observed in chronic hemodialysis patients. We studied 172 patients on chronic hemodialysis and 199 healthy adults. For analysis of the pentanucleotide repeat polymorphism,polymerase chain reaction products were loaded on polyacrylamide gel for electrophoresis. apo(a) size phenotyping was performed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. The median level of Lp(a) in the patients was 14.2 mg/dl which was significantly higher than that in controls (12.0 mg/dl; p < 0.05). In the genotype of (TTTTA)8/8, the median Lp(a) level in the patients (15.9 mg/dl) was significantly higher than that in controls (13.0 mg/dl; p < 0.05). In the genotype of (TTTTA)8/8 with large-sized apo(a) isoforms (A16-A25), the patients had significantly higher Lp(a) levels than the controls (p < 0.05). In conclusion, increased Lp(a) levels in chronic hemodialysis patients were mainly attributed to the combination of eight repeats of the pentanucleotide polymorphism and large-sized isoforms of apo(a).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:43:21