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Titolo:
Acute p-chloroamphetamine increases striatal preprotachykinin mRNA: role of the serotonin 2A/2C receptor
Autore:
Gresch, PJ; Walker, PD;
Indirizzi:
WayneNeurobioliv, Sch Med, Dept Psychiat & Behav Neurosci, Cellular & ClinWayne State Univ Detroit MI USA 48201 t & Behav Neurosci, Cellular & Clin Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 & Cell Biol, Detroit, MI 48201 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1, volume: 67, anno: 1999,
pagine: 190 - 193
SICI:
0169-328X(19990406)67:1<190:APISPM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; DOPAMINE RELEASE INVIVO; SUBSTANCE-P; GENE-EXPRESSION; TACHYKININ BIOSYNTHESIS; 5-HT2 RECEPTOR; BASAL GANGLIA; RAT-BRAIN; C-FOS; ACTIVATION;
Keywords:
dopamine; substance P; basal ganglia; alpha-methyl-p-tyrosine; ritanserin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, PD WayneNeurobioliv,ASch Med, Dept Psychiat & Behav Neurosci, Cellular & Clin Wayne State Univ 9352 Scott Hall,540 E Canfield Ave Detroit MI USA 48201
Citazione:
P.J. Gresch e P.D. Walker, "Acute p-chloroamphetamine increases striatal preprotachykinin mRNA: role of the serotonin 2A/2C receptor", MOL BRAIN R, 67(1), 1999, pp. 190-193

Abstract

Acute administration of p-chloroamphetamine (pCA) significantly increased (+90%) preprotachykinin (PPT) mRNA levels in the rat(2A/2C) receptor antagonist, ritanserin, blocked the pCA-induced increase in PPT mRNA levels. striatum. Administration of the serotonin alpha-Methyl-p-tyrosine pretreatment (alpha-MT, to reduce dopamine transmission) inhibited the pCA-induced increase in PPT mRNA levels. These results indicate that the pCa-induced increase in striatal PPT mRNA expression is mediated by serotonin(2A/2C) receptorsbut also requires dopamine tone. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:15:29