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Titolo:
Study of prognostic predictors for non-small cell lung cancer
Autore:
Fu, XL; Zhu, XZ; Shi, DR; Xiu, LZ; Wang, LJ; Zhao, S; Qian, H; Lu, HF; Xiang, YB; Jiang, GL;
Indirizzi:
Shanghaiinad Univ, Canc Hosp, Lung Canc Serv, Shanghai 200032, Peoples R Ch Shanghai Med Univ Shanghai Peoples R China 200032 i 200032, Peoples R Ch Shanghai Med Univ, Canc Hosp, Dept Pathol, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China Shanghai Canc Inst, Dept Epidemiol, Shanghai 200032, Peoples R China Shanghai Canc Inst Shanghai Peoples R China 200032 0032, Peoples R China
Titolo Testata:
LUNG CANCER
fascicolo: 2, volume: 23, anno: 1999,
pagine: 143 - 152
SICI:
0169-5002(199902)23:2<143:SOPPFN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAS ONCOGENE PRODUCT; DNA CONTENT; ONCOPROTEIN EXPRESSION; PROTEIN EXPRESSION; SHORTENED SURVIVAL; RADIATION-THERAPY; P-GLYCOPROTEIN; P53; CARCINOMA; MUTATIONS;
Keywords:
histology; non-small cell lung cancer; oncoprotein; prognostic index; prognostic predictor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Jiang, GL Shanghai0032,Univ, Canc Hosp, Lung Canc Serv, 399 Ling Ling Rd, Shanghai 20 Shanghai Med Univ 399 Ling Ling Rd Shanghai Peoples R China 200032
Citazione:
X.L. Fu et al., "Study of prognostic predictors for non-small cell lung cancer", LUNG CANC, 23(2), 1999, pp. 143-152

Abstract

Background: The outcome of treatment in non-small cell lung cancer (NSCLC)remains poor. One of the reasons is that in many patients its biological behavior does not follow a definite pattern, and can not be accurately predicted prior to treatment. In the present study we have examined the significant prognostic predictors. Methods: One hundred and fifty-eight patients with NSCLC entered this study. They received surgery alone (95 cases) or combined therapy with postoperative irradiation (63 cases). Three types of datahave been collected: (1) clinical characteristics: age, sex, Karnofsky performance status, weight loss, T stage, and N stage; (2) histopathology studies: histological types, tumor differentiation, status of vascular and lymphatic vessel invasions; (3) laboratory measurements by immunohistochemistryassay: oncoprotein overexpression, including pan-ras, c-myc, neu, epidermal growth factor receptor (EGFR) and p53, and tumor cell proliferation by proliferating cell nuclear antigen (PCNA). Results: For the entire group, 5-year actuarial survival, local control and distant metastasis rates were 44,63 and 40%, respectively. In the univariate analyses, T stage, N stage andlymphatic vessel invasion correlated to survival; T stage and N stage to local control; N stage, lymphatic vessel invasion and pan-res protein positive stain to distant metastasis. When the index of oncoprotein positive stains was used, the higher index was associated with a higher distant metastasis rate. In the multivariate analyses, T stage, N stage and lymphatic vessel invasion could be independent predictors for survival; T stage for local control; N stage, lymphatic vessel invasion and index of positive oncoprotein stains for distant metastasis. Conclusions: Late T and N stages, lymphatic vessel invasion and multi-oncoprotein positive stains would predict poorprognoses for NSCLC. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:18:56