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Titolo:
Involvement of diazepam binding inhibitor and its fragment octadecaneuropeptide in social isolation stress-induced decrease in pentobarbital sleep inmice
Autore:
Dong, EB; Matsumoto, K; Tohda, M; Watanabe, H;
Indirizzi:
ToyamaMed, & Pharmaceut Univ, Dept Pharmacol, Res Inst Wakan Yaku OrientalToyama Med & Pharmaceut Univ Toyama Japan 9300194 st Wakan Yaku Oriental
Titolo Testata:
LIFE SCIENCES
fascicolo: 19, volume: 64, anno: 1999,
pagine: 1779 - 1784
SICI:
0024-3205(19990402)64:19<1779:IODBIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FG-7142; BRAIN; RECEPTORS; BEHAVIOR; SYSTEMS; ODN;
Keywords:
social isolation stress; pentobarbitol sleep; diazepam binding inhibitor; octadecaneuropeptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, K ToyamaMed, & Pharmaceut Univ, Dept Pharmacol, Res Inst Wakan Yaku Oriental Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
E.B. Dong et al., "Involvement of diazepam binding inhibitor and its fragment octadecaneuropeptide in social isolation stress-induced decrease in pentobarbital sleep inmice", LIFE SCI, 64(19), 1999, pp. 1779-1784

Abstract

Diazepam binding inhibitor(DBI) and its fragment, octadecaneuropeptide (ODN), are putative endogenous ligands for benzodiazepine (BZD) receptors and have been shown to act as an inverse BZD receptor agonist in the brain. A previous study suggested that the social isolation stress-induced decrease in pentobarbital sleep in mice was partly due to endogenous substances with an inverse BZD receptor agonist-like property. In this study, we examined the effects of DBI and ODN on pentobarbital sleep in group-housed and socially isolated mice to test the possible involvement of DBI and ODN in a social isolation-induced decrease in pentobarbital sleep. The socially isolated mice showed significantly shorter durations of pentobarbital (50 mg/kg, intraperitoneally, i.p.) sleep compared to the group-housed animals. When injected intracerebroventricularly (i.c.v.), DBI and ODN (3 and 10 nmol) dose-dependently shortened the pentobarbital-induced sleeping time in group-housed mice at the same dose range, but these peptides had no effect on the sleeping time in socially isolated animals. In contrast, flumazenil (16.5-33 nmol, i.c.v.), a BZD receptor antagonist, reversed the pentobarbital sleepingtime in socially isolated mice to the level of group-housed animals without affecting the sleeping time in group-housed animals. The effects of DBI and ODN in. group-housed mice were significantly blocked by flumazenil (33 nmol, i.c.v.). Moreover, the effect of flumazenil in socially isolated mice was significantly attenuated by DBI and ODN (10 nmol, i.c.v.). These results suggest that the changes in the activity of DBI and/or ODN are partly involved in the social isolation-induced decrease in the hypnotic action of pentobarbital in mice.

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Documento generato il 02/10/20 alle ore 01:36:08