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Titolo:
The binding of [H-3]AF-DX 384 is reduced in the Caudate-Putamen of subjects with schizophrenia
Autore:
Crook, JM; Dean, B; Pavey, G; Copolov, D;
Indirizzi:
Mentalaliah Res Inst, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Austr Mental Hlth Res Inst Parkville Vic Australia 3052 kville, Vic 3052, Austr Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
LIFE SCIENCES
fascicolo: 19, volume: 64, anno: 1999,
pagine: 1761 - 1771
SICI:
0024-3205(19990402)64:19<1761:TBO[3I>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC CHOLINERGIC RECEPTORS; RAT-BRAIN; ANTISCHIZOPHRENIC DRUGS; NEGATIVE SYMPTOMS; MESSENGER-RNAS; M2 RECEPTORS; IN-VIVO; IDENTIFICATION; LOCALIZATION; BENZTROPINE;
Keywords:
schizophrenia; muscarinic receptor levels; antipsychotic drug effects; human brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Crook, JM MentalVicth Res Inst, Rebecca L Cooper Res Labs, Locked Bag 11, Parkville, Mental Hlth Res Inst Locked Bag 11 Parkville Vic Australia 3052
Citazione:
J.M. Crook et al., "The binding of [H-3]AF-DX 384 is reduced in the Caudate-Putamen of subjects with schizophrenia", LIFE SCI, 64(19), 1999, pp. 1761-1771

Abstract

Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [H-3]AF-DX 384 labelled receptors (muscarinic M-2 and M-4) in the caudate-putamen, obtained at autopsy, from 19 subjects who had schizophrenia, and 20 subjects who did not have schizophrenia. [H-3]AF-DX 384 binding was reduced in caudate-putamen from schizophrenic subjects (104 +/- 10.3 v(s) 145 +/- 901 fmol mg(-1) TE; mean +/- s.e.; p = 0.007). Preliminary analysis of patient drug data as well as rat studies suggest that the reduced [H-3]AF-DX 384 binding in caudate-putamen of schizophrenic subjects is not wholly due to antipsychotic drug treatment, or anticholinergic medication for the treatment of extrapyramidal effects. These data suggest that the muscarinic cholinergic system may be involved in the pathology of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:34:19