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Titolo:
p16(INK4a) alterations in gastrinomas and non-functioning islet cell carcinomas
Autore:
Bartsch, D; Kersting, M; Schilling, T; Ramaswamy, A; Gerdes, B; Bastian, D; Schuermann, M; Rothmund, M;
Indirizzi:
Univ Marburg, Klin Allgemeinchirurg, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 inchirurg, D-35033 Marburg, Germany Univ Marburg, Zentrum Pathol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 um Pathol, D-35033 Marburg, Germany
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
, , anno: 1999, supplemento:, 1
pagine: 543 - 546
SICI:
1435-2443(1999):<543:PAIGAN>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Soggetto:
MUTATIONS; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Bartsch, D Univ Marburg, Klin Allgemeinchirurg, Baldingerstr, D-35033 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35033 urg, Germany
Citazione:
D. Bartsch et al., "p16(INK4a) alterations in gastrinomas and non-functioning islet cell carcinomas", LANG ARCH S, 1999, pp. 543-546

Abstract

Background/Aim: Molecular mechanisms contributing to the tumorigenesis of neuroendocrine pancreatic tumors are still poorly understood. Therfore we evaluated the role of the p16(INK4) tumor suppressor gene for the genesis ofthese tumors. Methods: Ten non-functioning islet cell carcinomas and 8 gastrinomas were analysed for alterations in the p16(INK4a) tumor suppressor gene by SSCP, PCR based deletion assay and a methylation-specific PCR. Results: Seven (70%) non-functioning islet cell carcinomas and 2 malignantgastrinomas (25%) showed aberrant hypermethylation or homozygous deletion of the p16(INK4a) gene. Conclusions: The p16(INK4a) tumor suppressor gene plays an important role in the tumorigenesis of non-functioning islet cell carcinomas and malignantgastrinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:41:07