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Titolo:
Brain regions involved in articulation
Autore:
Wise, RJS; Greene, J; Buchel, C; Scott, SK;
Indirizzi:
Univonondon Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Cyclotr Univ London Imperial Coll Sci Technol & Med London England W12 0NN clotr Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nit Neurol, London WC1N 3BG, England MRC, Appl Psychol Unit, Cambridge CB2 2EF, England MRC Cambridge EnglandCB2 2EF l Psychol Unit, Cambridge CB2 2EF, England
Titolo Testata:
LANCET
fascicolo: 9158, volume: 353, anno: 1999,
pagine: 1057 - 1061
SICI:
0140-6736(19990327)353:9158<1057:BRIIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN AUDITORY-CORTEX; COORDINATING SPEECH ARTICULATION; ANATOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wise, RJS Univonondon Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Cyclotr Univ London Imperial Coll Sci Technol & Med London England W12 0NN
Citazione:
R.J.S. Wise et al., "Brain regions involved in articulation", LANCET, 353(9158), 1999, pp. 1057-1061

Abstract

Background The left inferior frontal gyrus (Broca's area) is generally believed to be critical for the motor act of speech. A lesion-based analysis has, however, shown that the left anterior insula is necessary for accurate articulation. We used functional imaging in normal people to show the neural systems involved in speech during different speech tasks. Methods 12 normal people underwent positron emission tomography with oxygen-15-labelled water as tracer. We measured cerebral activity while participants performed three different tasks: repetition of heard nouns at different rates; listening to single nouns at different rates; and anticipation of listening or repetition. We analysed the data with imaging software. Findings Repetition of single words did not activate Broca's area but activity in three left-lateralised regions was seen: the anterior insula, a localised region in the lateral premotor cortex, and the posterior pallidum. The left anterior insula and lateral premotor cortex showed a conjunction ofactivity for hearing and articulation. In addition, articulation modulatedthe response to hearing words in the left dorsolateral temporal cortex, the physiological expression of the speaker's auditory attention being directed towards the stimuli and not his or her articulated responses. Interpretation The formulation of an articulatory plan is a function of the left anterior insula and lateral premotor cortex and not of Broca's area. The left basal ganglia seem to be dominant for speech, although the axial muscles involved receive their motor output from both cerebral hemispheres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:28:26