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Titolo:
Advanced glycation end products in children and adolescents with diabetes:Relation to glycemic control and early microvascular complications
Autore:
Chiarelli, F; de Martino, M; Mezzetti, A; Catino, M; Morgese, G; Cuccurullo, F; Verrotti, A;
Indirizzi:
Univ Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Chieti Chieti Italy iv Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Siena, Dept Pediat, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Siena, Dept Pediat, I-53100 Siena, Italy
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 4, volume: 134, anno: 1999,
pagine: 486 - 491
SICI:
0022-3476(199904)134:4<486:AGEPIC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED GLYCOSYLATION; AMINOGUANIDINE; NEPHROPATHY; MELLITUS; DISEASE; PATHWAY; TISSUE; IDDM; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chiarelli, F Osped Policlin, Pediat Clin, Via dei Vestini 5, I-66100 Chieti, Italy Osped Policlin Via dei Vestini 5 Chieti Italy I-66100 Italy
Citazione:
F. Chiarelli et al., "Advanced glycation end products in children and adolescents with diabetes:Relation to glycemic control and early microvascular complications", J PEDIAT, 134(4), 1999, pp. 486-491

Abstract

Objective: The measurement of serum advanced glycation end products (S-AGEs) in children, adolescents, and young adults with diabetes to determine whether increased S-AGE levels may be associated with long-term glycemic control and early microvascular complications. Study design: The study was performed in (1) 178 children and adolescents with type 1 diabetes mellitus (age range, 2 to 21 years, onset before the age of 12 years; duration longer than 2 years) without clinical and laboratory signs of microvascular complications, (2) 39 adolescents and young adults (age range, 16.1 to 28.8 years) with background or preproliferative retinopathy or persistent microalbuminuria, and (3) 98 healthy age- and sex-matched control subjects. Results: S-AGEs were significantly increased in preschool and prepubertal children with diabetes and were particularly elevated in pubertal subjects with diabetes compared with control subjects. S-AGEs were markedly in creased in adolescents with early microvascular complications compared with bothcontrol subjects and diabetic patients without retinopathy or nephropathy. No correlation was found between S-AGEs and albumin excretion rate or blood pressure values. Glycated hemoglobulin values and S-AGEs were significantly correlated (r = 0.32; P < .01). In children with poorly controlled diabetes (HbA(1)c >10%), long-term (2 years) improvement of glycemic control resulted in a significant reduction of S-AGE levels in preschool and prepubertal children, as well as in pubertal individuals. Conclusions: S-AGE concentrations may be elevated even in preschool and prepubertal children with diabetes; this means that the risk of microvascularcomplications may be present at an early age. Improvement in glycemic control may be associated with a significant decrease in S-AGEs.

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Documento generato il 16/07/20 alle ore 20:00:36