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Titolo:
Role of intraepithelial lymphocytes in mucosal immune responses of mice experimentally infected with Cryptosporidium parvum
Autore:
Chai, JY; Guk, SM; Han, HK; Yun, CK;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Parasitol, Seoul 110799, South Korea SeoulNatl Univ Seoul South Korea 110799 itol, Seoul 110799, South Korea Seoul Natl Univ, Med Res Ctr, Inst Endem Dis, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 Dis, Seoul 110799, South Korea
Titolo Testata:
JOURNAL OF PARASITOLOGY
fascicolo: 2, volume: 85, anno: 1999,
pagine: 234 - 239
SICI:
0022-3395(199904)85:2<234:ROILIM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; MURINE SMALL; SCID MICE; IFN-GAMMA; CELLS; OOCYSTS; ALPHA/BETA; RESOLUTION; INTESTINE; CALVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Chai, JY Seoul Natl Univ, Coll Med, Dept Parasitol, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 ul 110799, South Korea
Citazione:
J.Y. Chai et al., "Role of intraepithelial lymphocytes in mucosal immune responses of mice experimentally infected with Cryptosporidium parvum", J PARASITOL, 85(2), 1999, pp. 234-239

Abstract

In order to investigate the role of intestinal intraepithelial lymphocytes(IELs) in host defense against Cryptosporidium parvum infection, conventionally bred immunocompetent (ImCT) ICR mice and immunosuppressed (ImSP) littermates were infected orally with 10(6) C. parvum oocysts. Then fecal oocyst excretion, the number and location of IELs, and their T lymphocyte subsets were observed on days 4, 7, 10, 13, 16, and 20 postinfection (PI). Uninfected ImCT and ImSP mice were used as controls. The starring point of oocystexcretion was day 4 PI in both ImCT- and ImSP-infected mice. The highest oocyst excretion occurred on day 7 PI in both groups, though the number of oocysts excreted was 3 times greater in ImSP than in ImCT mice. In ImCT mice, IELs greatly increased in number on days 16 and 20 PI (P < 0.05), but theincrease was minimal in ImSP mice. IELs changed their location from the basal area to intermediate and apical areas of villous epithelial cells during the early stage of infection. In ImCT-infected mice, IEL phenotypes also changed: whereas CD4(+) cells increased temporarily on day 7 PI (P < 0.05),CD8(+) cells increased significantly on days 16 and 20 PI (P < 0.05). The results strongly suggest that IELs play a significant role in host defense against C. parvum infection, with helper T cells initiating control of the infection and cytotoxic T cells eliminating the parasites.

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Documento generato il 07/07/20 alle ore 15:41:18