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Titolo:
Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection
Autore:
Mendell, LM; Johnson, RD; Munson, JB;
Indirizzi:
SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 ehav, Stony Brook, NY 11794 USA Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 siol Sci, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 19, anno: 1999,
pagine: 3162 - 3170
SICI:
0270-6474(19990415)19:8<3162:NMOTMR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IA AFFERENT-FIBERS; RETROGRADE AXONAL-TRANSPORT; HIGH-FREQUENCY STIMULATION; SPINAL MOTOR-NEURONS; SENSORY NEUROPATHY; MOTONEURON SYNAPSE; EPSP AMPLITUDE; NEWBORN RATS; MUSCLE; AXOTOMY;
Keywords:
NT-3; NT-4/5; neurotrophin; motoneuron; motor neuron; muscle spindle; group la fiber; spinal cord; axotomy; EPSP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Mendell, LM SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Brook, NY 11794 USA
Citazione:
L.M. Mendell et al., "Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection", J NEUROSC, 19(8), 1999, pp. 3162-3170

Abstract

The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axotomized group la afferents and motoneurons comprising the monosynaptic reflex pathway were investigated. The axotomized medial gastrocnemius (MG) nerve was provided with NT-3 or NT-4/5 for 8-35 d via an osmotic minipump attached to its central end at the time of axotomy. After this treatment. monosynaptic EPSPs were recorded intracellularly from MG or lateral gastrocnemius soleus (LGS) motoneurons in response to stimulation of the heteronymous nerve under pentobarbital anesthesia. Controls were preparations with axotomized nerves treated directly with vehicle; other axotomized controls were administered subcutaneous NT-3. Direct NT-3 administration (60 mu g/d) not only prevented the decline in EPSP amplitude from axotomized afferents (stimulateMG, record LGS) observed in axotomy controls but, after 5 weeks, led to EPSPs larger than those from intact afferents. These central changes were paralleled by recovery of group I afferent conduction velocity. Removal of NT-3 4-5 weeks after beginning treatment resulted in a decline of conduction velocity and EPSP amplitude within 1 week to values characteristic of axotomy, The increased synaptic efficacy after NT-3 treatment was associated withenhanced connectivity of single afferents to motoneurons. NT-4/5 induced modest recovery in group I afferent conduction velocity but not of the EPSPsthey elicited. NT-3 or NT-4/5 had no effect on the properties of treated motoneurons or their monosynaptic EPSPs. We conclude that NT-3, and to a limited extent NT-4/5, promotes recovery of axotomized group la afferents but not axotomized motoneurons or the synapses on them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:30:06