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Titolo:
Differential c-Fos expression in cholinergic, monoaminergic, and GABAergiccell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery
Autore:
Maloney, KJ; Mainville, L; Jones, BE;
Indirizzi:
McGillAUniv, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3 McGill Univ Montreal PQ Canada H3A 2B4 eurol & Neurosurg, Montreal, PQ H3
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 19, anno: 1999,
pagine: 3057 - 3072
SICI:
0270-6474(19990415)19:8<3057:DCEICM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; FREELY MOVING CATS; DORSAL RAPHE NEURONS; INDUCED ACTIVE SLEEP; INDUCED REM-SLEEP; BRAIN-STEM; ACETYLCHOLINE-RELEASE; BASAL FOREBRAIN; WAKING CYCLE; NORADRENERGIC NEURONS;
Keywords:
paradoxical sleep; c-Fos expression; cholinergic; serotonergic; noradrenergic; GABAergic; sleep-wake states;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, BE McGillontreal,ontreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, M McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 1 Univ St, M
Citazione:
K.J. Maloney et al., "Differential c-Fos expression in cholinergic, monoaminergic, and GABAergiccell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery", J NEUROSC, 19(8), 1999, pp. 3057-3072

Abstract

Multiple lines of evidence indicate that neurons within the pontomesencephalic tegmentum are critically involved in the generation of paradoxical sleep (PS). From single-unit recording studies, evidence suggests that unidentified but "possibly" cholinergic tegmental neurons discharge at higher rates during PS than during slow wave sleep or even waking and would thus play an active role, whereas "presumed" monoaminergic neurons cease firing during PS and would thus play a permissive role in PS generation. In the presentstudy performed on rats, c-Fos immunostaining was used as a reflection of neuronal activity and combined with immunostaining for choline acetyltransferase (ChAT), serotonin (Ser), tyrosine hydroxylase (TH), or glutamic acid decarboxylase (GAD) for immunohistochemical identification of active neurons during PS recovery (similar to 28% of recording time) as compared with PSdeprivation (0%) and PS control (similar to 15%) conditions. With PS recovery, there was a significant increase in ChAT+/c-Fos+ cells, a significant decrease in Ser+/c-Fos+ and TH+/c-Fos+ cells, and a significant increase inGAD+/c-Fos+ cells. Across conditions, the percent PS was correlated positively with tegmental cholinergic c-Fos+ cells, negatively with raphe serotonergic and locus coeruleus noradrenergic c-Fos+ cells, and positively with codistributed and neighboring GABAergic c-Fos+ cells. These results support the hypothesis that cholinergic neurons are active, whereas monoaminergic neurons are inactive during PS. They moreover indicate that GABAergic neurons are active during PS and could thus be responsible for inhibiting neighboring monoaminergic neurons that may be essential in the generation of PS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:02:23