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Titolo:
Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline afterlong-term occupational solvent exposure
Autore:
Hageman, G; van der Hoek, J; van Hout, M; van der Laan, G; Steur, EJ; de Bruin, W; Herholz, K;
Indirizzi:
Hosprlandsede, Med Spectrum Twente, Dept Neurol, NL-7500 KA Enschede, Nethe Hosp Enschede Enschede Netherlands NL-7500 KA NL-7500 KA Enschede, Nethe UnivDDmsterdam, Acad Med Ctr, Dutch Ctr Occupat Dis, Coronel Inst, NL-1100Univ Amsterdam Amsterdam Netherlands NL-1100 DD s, Coronel Inst, NL-1100 Hosp Enschede, Med Spectrum Twente, Dept Clin Psychol, NL-7500 KA Enschede, Hosp Enschede Enschede Netherlands NL-7500 KA chol, NL-7500 KA Enschede, Hospherlandse, Med Spectrum Twente, Dept Nucl Med, NL-7500 KA Enschede, Net Hosp Enschede Enschede Netherlands NL-7500 KA , NL-7500 KA Enschede, Net Univ4Hosp Cologne, Max Planck Inst, Lab PET, Dept Psychiat & Neurol, D-5092 Univ Hosp Cologne Cologne Germany D-50924 Dept Psychiat & Neurol, D-5092
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 3, volume: 246, anno: 1999,
pagine: 198 - 206
SICI:
0340-5354(199903)246:3<198:PPSPAC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; N-HEXANE; NEUROLOGIC SEQUELAE; TOLUENE ABUSE; DISEASE; WORKERS; PET; INTOXICATION;
Keywords:
Parkinsonism; solvents; neurotoxicity; occupational disease; chronic toxic encephalopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Hageman, G Hosphede,hede, Med Spectrum Twente, Dept Neurol, POB 50000, NL-7500 KA Ensc Hosp Enschede POB 50000 Enschede Netherlands NL-7500 KA A Ensc
Citazione:
G. Hageman et al., "Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline afterlong-term occupational solvent exposure", J NEUROL, 246(3), 1999, pp. 198-206

Abstract

It is well known that exposure to manganese, solvents, or carbon monoxide in an occupational setting may lead to central nervous system damage and parkinsonism. The most important solvents in this respect are methanol, toluene, carbon disulfide, and n-hexane, We describe three patients who had beenexposed to various solvents for more than 20 years (25, 34, and 46 years). They presented with parkinsonism, pyramidal signs, mild cognitive decline,and unresponsiveness to levodopa, Two patients had a predominantly axonal and sensory polyneuropathy of the lower legs with fasciculations in one of them. Parkinsonian features were progressive, even after the patients had stopped work. We present clinical data, neuropsychological findings, and results of brain computed tomography or magnetic resonance imaging, electroneuromyography, evoked potentials, single photon emission computed tomography,and positron-emission tomography. There is growing evidence that various organic solvents give rise to a parkinsonism syndrome with pyramidal features in susceptible individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:40:49