Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Elevated levels of interleukin-12 and interferon-gamma in patients with human T lymphotropic virus type I associated myelopathy
Autore:
Furuya, T; Nakamura, T; Fujimoto, T; Nakane, S; Kambara, C; Shirabe, S; Hamasaki, S; Motomura, M; Eguchi, K;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Internal Med 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 rnal Med 1, Nagasaki 8528501, Japan
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 95, anno: 1999,
pagine: 185 - 189
SICI:
0165-5728(19990301)95:1-2<185:ELOIAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HTLV-I; INFLAMMATORY CYTOKINES; CELLS;
Keywords:
HAM; Th1; Th2; IL-12; IFN-gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, T Nagasaki01,iv, Sch Med, Dept Internal Med 1, 1-7-1 Sakamoto, Nagasaki 85285 Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 aki 85285
Citazione:
T. Furuya et al., "Elevated levels of interleukin-12 and interferon-gamma in patients with human T lymphotropic virus type I associated myelopathy", J NEUROIMM, 95(1-2), 1999, pp. 185-189

Abstract

The levels of interleukin-12 (IL-12) (p70 heterodimer), total IL-12 (p70 heterodimer plus p40 chains), interferon-gamma (IFN-gamma) as Th1 cytokine, and those of interleukin-4 (IL-4) and interleukin-10 (IL-10) as Th2 cytokines in sera and cerebrospinal fluid (CSF) from 22 patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) were compared with those of 22 patients with other neurological diseases (OND), including nine anti-HTLV-I-seropositive carriers. Both serum IL-12 (total and p70 heterodimer) and CSF IFN-gamma, measured by the enzyme-linked immunosorbent assay (ELISA), were significantly elevated in patients with HAM as compared tothe patients with OND, including the anti-HTLV-I-seropositive carriers. Serum IFN-gamma also was significantly elevated in the HAM patients as compared to the controls. There was no significant difference in the CSF levels of IL-12 (total and p70 heterodimer) between the HAM patients and controls, whereas, for the Th2 cytokines IL-4 was detected in the CSF of four anti-HTLV-I-seropositive carriers of the 13 control patients but not in any of thepatients with HAM. No significant difference was found in the serum levelsof IL-4 and IL-10, nor in the CSF levels of IL-10 in the patients with HAMand in the controls. These findings indicate that in patients with HAM, the immunological balance of helper T lymphocytes between Th1 and Th2 is toward Th1 in the periphery and that Th1-mediated immunological status in the central nervous system is involved in the pathogenesis of HAM. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:57:40