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Titolo:
Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4(+) epitope sequences of the acetylcholine receptor
Autore:
Karachunski, PI; Ostlie, NS; Okita, DK; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Coll Biol Sci, Dept Biochem, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 , Dept Biochem, St Paul, MN 55108 USA Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 95, anno: 1999,
pagine: 73 - 84
SICI:
0165-5728(19990301)95:1-2<73:IDFDOE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL-ALLERGIC-ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; T-CELL RECOGNITION; DIABETIC NOD MICE; IFN-GAMMA; INTERFERON-GAMMA; IL-4-DEFICIENT MICE; IMMUNE-RESPONSE; ORAL TOLERANCE;
Keywords:
acetylcholine receptor; experimental myasthenia gravis; Th2 cells; nasal tolerance; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ55108esota, Coll Biol Sci, Dept Biochem, 1479 Gortner Ave, St Paul, MN Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 ul, MN
Citazione:
P.I. Karachunski et al., "Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4(+) epitope sequences of the acetylcholine receptor", J NEUROIMM, 95(1-2), 1999, pp. 73-84

Abstract

Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). We investigated EMG in interleukin (IL)-4 knock out B6 (KO) mice, that lack Th2 cells. EMG was mon frequent in KO than in wild typeB6 mice. KO and B6 mice developed similar amounts of anti-AChR antibodies. They were IgG2a and IgG2b in KO mice, IgG1 and IgG2b in B6 mice. CD4(+) cells from KO and B6 mice recognized the same AChR epitopes. Nasal administration of synthetic AChR CD4(+) epitopes reduced antibody synthesis and prevented EMG in B6, not in KO mice. Thus, Th2 cells may have protective functions in EMG. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:21:01