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Titolo:
Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins
Autore:
Henderson, HE; Kastelein, JJP; Zwinderman, AH; Gagne, E; Jukema, JW; Reymer, PWA; Groenemeyer, BE; Lie, KI; Bruschke, AVG; Hayden, MR; Jansen, H;
Indirizzi:
Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada d Genet, Vancouver, BC, Canada Univ Cape Town, Dept Chem Pathol, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa Univ Amsterdam, Dept Vasc Med, Lipid Res Grp, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands id Res Grp, Amsterdam, Netherlands Leiden Univ, Dept Med Stat, NL-2300 RA Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RA NL-2300 RA Leiden, Netherlands Univ Leiden Hosp, Dept Cardiol, NL-2300 RC Leiden, Netherlands Univ LeidenHosp Leiden Netherlands NL-2300 RC 00 RC Leiden, Netherlands Univ Amsterdam, Dept Cardiol, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands pt Cardiol, Amsterdam, Netherlands Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands Interuniv CardiolInst Netherlands Utrecht Netherlands cht, Netherlands Erasmus Univ, Dept Biochem, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 4, volume: 40, anno: 1999,
pagine: 735 - 743
SICI:
0022-2275(199904)40:4<735:LLAIDI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; HEPARIN PLASMA-LIPOPROTEIN; HEPATIC LIPASE; MISSENSE MUTATION; POSTPRANDIAL LIPEMIA; TRIGLYCERIDE LEVELS; CHOLESTEROL LEVELS; NONSENSE MUTATION; APOLIPOPROTEIN-E; HDL CHOLESTEROL;
Keywords:
REGRESS study; VLDL; LDL; HDL; cholesterol; triglyceride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Kastelein, JJP Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada ver, BC, Canada
Citazione:
H.E. Henderson et al., "Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins", J LIPID RES, 40(4), 1999, pp. 735-743

Abstract

Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparinLPL (PH-LPL) activity and lipids and lipoproteins in a large, well-definedcohort of Dutch males with coronary artery disease (CAD), These subjects were: drawn from the REGRESS study, totaled 730 in number and were evaluatedagainst 75 healthy, normolipidemic male controls. Easting mean PH-LPL activity in the CAD subjects was 108 (46) mU/ml, compared to 138 (44) mU/ml in controls (P < 0.0001). When these patients were divided into activity quartiles, those in the lowest versus the highest quartile had higher levels of TG (P < 0.001), VLDLc and VLDL-TG (P = 0.001). Conversely, levels of TC, LDL, and HDLc were lower in these patients (P = 0.001, P = 0.02, and P = 0.001, respectively). Also, in this cohort PH-LPL relationships with lipids andlipoproteins were not altered by apoE genotypes, The frequency of common mutations in the LPL gene associated with partial LPL deficiency (N291S and D9N carriers) in the lowest quartile for LPL activity was more than double the frequency in the highest quartile (12.0% vs. 5.0%; P = 0.006). By contrast, the frequency of the S447X LPL variant rose from 11.5% in the lowest to 18.3% (P = 0.006) in the highest quartile. This study, in a large cohort of CAD patients, has shown that PH-LPL activity is decreased (22%; P = 0.001) when compared to controls; that the D9N and N291S, and S447X LPL variants are genetic determinants, respectively, in CAD patients of low and high LPL PH-LPL activities; and that PH-LPL activity is strongly associated with changes in lipids and lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:05:45