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Titolo:
Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children
Autore:
Luty, AJF; Lell, B; Schmidt-Ott, R; Lehman, LG; Luckner, D; Greve, B; Matousek, P; Herbich, K; Schmid, D; Migot-Nabias, F; Deloron, P; Nussenzweig, RS; Kremsner, PG;
Indirizzi:
Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 asitol, D-72074 Tubingen, Germany Albert Schweitzer Hosp, Res Unit, Lambarene, Gabon Albert Schweitzer HospLambarene Gabon Hosp, Res Unit, Lambarene, Gabon Ctr Int Rech Med Franceville, Franceville, Gabon Ctr Int Rech Med Franceville Franceville Gabon ille, Franceville, Gabon Univ Vienna, Dept Infect Dis, Vienna, Austria Univ Vienna Vienna Austria niv Vienna, Dept Infect Dis, Vienna, Austria NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY USA NYU New York NY USA Sch Med, Dept Med & Mol Parasitol, New York, NY USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 4, volume: 179, anno: 1999,
pagine: 980 - 988
SICI:
0022-1899(199904)179:4<980:IRAAWR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MEROZOITE SURFACE-ANTIGEN; NITRIC-OXIDE SYNTHASE; HUMORAL IMMUNE-RESPONSES; LIVER-STAGE ANTIGEN-1; NEW-GUINEAN CHILDREN; PAPUA-NEW-GUINEA; CD8+ T-CELLS; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Luty, AJF Univen,bingen, Inst Trop Med, Dept Parasitol, Wilhelmstr 27, D-72074 Tubing Univ Tubingen Wilhelmstr 27 Tubingen Germany D-72074 074 Tubing
Citazione:
A.J.F. Luty et al., "Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children", J INFEC DIS, 179(4), 1999, pp. 980-988

Abstract

The contribution of T cell-mediated responses was studied with regard to resistance to reinfection in groups of Gabonese children participating In a prospective study of severe and mild malaria due to infection with Plasmodium falciparum. In those admitted with mild malaria, but not in those with severe malaria, production of IFN-gamma by peripheral blood mononuclear cells (PBMC) in response to either liver-stage or merozoite antigen peptides was associated with significantly delayed first reinfections and with significantly lower rates of reinfection. Proliferative or tumor necrosis factor responses to the same peptides showed no such associations. Production of interferon-gamma by PBMC in response to sporozoite and merozoite antigen peptides was observed in a higher proportion of those presenting with mild malaria. Differences in the Th1/Th2 cytokine balance may be linked. to the ability to control parasite multiplication in these young children, helping to explain the marked differences observed in both susceptibility to infectionas well as in clinical presentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:16:49